Compile Data Set for Download or QSAR
Report error Found 74 Enz. Inhib. hit(s) with all data for entry = 50008363
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50236871(CHEMBL4069231)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human KOR expressed in HEK293T cells assessed as inhibition of Galphai-mediated cAMP accumulation after 15 mins by microbeta coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518468(CHEMBL4462000)
Affinity DataEC50:  17nMAssay Description:Agonist activity at Tango-KOR (unknown origin) expressed in HTLA cells harboring TEV-fused-beta-arrestin 2 assessed as increase in beta arrestin 2 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518464(CHEMBL4561040)
Affinity DataEC50:  33nMAssay Description:Agonist activity at Tango-KOR (unknown origin) expressed in HTLA cells harboring TEV-fused-beta-arrestin 2 assessed as increase in beta arrestin 2 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518467(CHEMBL4438714)
Affinity DataEC50:  247nMAssay Description:Agonist activity at Tango-KOR (unknown origin) expressed in HTLA cells harboring TEV-fused-beta-arrestin 2 assessed as increase in beta arrestin 2 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518466(CHEMBL4463652)
Affinity DataEC50:  43nMAssay Description:Agonist activity at Tango-KOR (unknown origin) expressed in HTLA cells harboring TEV-fused-beta-arrestin 2 assessed as increase in beta arrestin 2 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50236871(CHEMBL4069231)
Affinity DataEC50:  3.80nMAssay Description:Agonist activity at Tango-KOR (unknown origin) expressed in HTLA cells harboring TEV-fused-beta-arrestin 2 assessed as increase in beta arrestin 2 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518465(CHEMBL4582146)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human KOR expressed in HEK293T cells assessed as inhibition of Galphai-mediated cAMP accumulation after 15 mins by microbeta coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50159165(2S,4aR,6a(R,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataEC50:  0.0150nMAssay Description:Agonist activity at human KOR expressed in HEK293T cells assessed as inhibition of Galphai-mediated cAMP accumulation after 15 mins by microbeta coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518467(CHEMBL4438714)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human KOR expressed in HEK293T cells assessed as inhibition of Galphai-mediated cAMP accumulation after 15 mins by microbeta coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518461(CHEMBL4467644)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human KOR expressed in HEK293T cells assessed as inhibition of Galphai-mediated cAMP accumulation after 15 mins by microbeta coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50159165(2S,4aR,6a(R,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataEC50:  5.10nMAssay Description:Agonist activity at Tango-KOR (unknown origin) expressed in HTLA cells harboring TEV-fused-beta-arrestin 2 assessed as increase in beta arrestin 2 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518470(CHEMBL4555496)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human KOR expressed in HEK293T cells assessed as inhibition of Galphai-mediated cAMP accumulation after 15 mins by microbeta coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518465(CHEMBL4582146)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at Tango-KOR (unknown origin) expressed in HTLA cells harboring TEV-fused-beta-arrestin 2 assessed as increase in beta arrestin 2 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518466(CHEMBL4463652)
Affinity DataEC50:  2.80nMAssay Description:Agonist activity at human KOR expressed in HEK293T cells assessed as inhibition of Galphai-mediated cAMP accumulation after 15 mins by microbeta coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518470(CHEMBL4555496)
Affinity DataEC50:  227nMAssay Description:Agonist activity at Tango-KOR (unknown origin) expressed in HTLA cells harboring TEV-fused-beta-arrestin 2 assessed as increase in beta arrestin 2 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518464(CHEMBL4561040)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human KOR expressed in HEK293T cells assessed as inhibition of Galphai-mediated cAMP accumulation after 15 mins by microbeta coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518462(CHEMBL4483681)
Affinity DataEC50:  42nMAssay Description:Agonist activity at Tango-KOR (unknown origin) expressed in HTLA cells harboring TEV-fused-beta-arrestin 2 assessed as increase in beta arrestin 2 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518461(CHEMBL4467644)
Affinity DataEC50:  12nMAssay Description:Agonist activity at Tango-KOR (unknown origin) expressed in HTLA cells harboring TEV-fused-beta-arrestin 2 assessed as increase in beta arrestin 2 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518462(CHEMBL4483681)
Affinity DataEC50:  8.10nMAssay Description:Agonist activity at human KOR expressed in HEK293T cells assessed as inhibition of Galphai-mediated cAMP accumulation after 15 mins by microbeta coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518468(CHEMBL4462000)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity at human KOR expressed in HEK293T cells assessed as inhibition of Galphai-mediated cAMP accumulation after 15 mins by microbeta coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50236871(CHEMBL4069231)
Affinity DataKi:  0.540nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-13-ox...)
Affinity DataKi:  0.690nMAssay Description:Displacement of [3H]diprenorphine from human KOR expressed in HEK293T cell membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM21130(U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...)
Affinity DataKi:  0.970nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50039029(CHEMBL13470 | 3-[(4-Allyl-2,5-dimethyl-piperazin-1...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]DPDPE from DOR in Sprague-Dawley rat brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50130757(CHEMBL3634516)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518465(CHEMBL4582146)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518463(CHEMBL4435256)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518468(CHEMBL4462000)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]DAMGO from MOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518469(CHEMBL4518180)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518462(CHEMBL4483681)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518461(CHEMBL4467644)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50236871(CHEMBL4069231)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]diprenorphine from human KOR expressed in HEK293T cell membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]DAMGO from MOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50001028(Talwin | PENTAZOCINE (+) | Pentazocine,(+/-) | 6,1...)
Affinity DataKi:  5.40nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518466(CHEMBL4463652)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518464(CHEMBL4561040)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataKi:  7.30nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518471(CHEMBL4451876)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518465(CHEMBL4582146)
Affinity DataKi:  9.20nMAssay Description:Displacement of [3H]diprenorphine from human KOR expressed in HEK293T cell membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518468(CHEMBL4462000)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]diprenorphine from human KOR expressed in HEK293T cell membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518461(CHEMBL4467644)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]diprenorphine from human KOR expressed in HEK293T cell membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518470(CHEMBL4555496)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518464(CHEMBL4561040)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]diprenorphine from human KOR expressed in HEK293T cell membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518462(CHEMBL4483681)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]diprenorphine from human KOR expressed in HEK293T cell membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518467(CHEMBL4438714)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]diprenorphine from human KOR expressed in HEK293T cell membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518466(CHEMBL4463652)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]diprenorphine from human KOR expressed in HEK293T cell membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518470(CHEMBL4555496)
Affinity DataKi:  77nMAssay Description:Displacement of [3H]diprenorphine from human KOR expressed in HEK293T cell membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  78nMAssay Description:Displacement of [3H]DTG from sigma2 receptor in rat liver membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
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