Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50007292
TargetVascular endothelial growth factor receptor 2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human GST-fused EGFR kinase domain expressed in baculovirus expression system measured after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human A431 cell-derived EGFR assessed as reduction in PGT phosphorylation after 8 mins by colorimetry based immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human A431 cell-derived EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508274(CHEMBL4436625)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant human GST-fused B-Raf V600E mutant using MEK1 as substrate measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508271(CHEMBL4539051)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human GST-fused EGFR kinase domain expressed in baculovirus expression system measured after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 1(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508273(CHEMBL4589270)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508273(CHEMBL4589270)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508277(CHEMBL4548316)
Affinity DataIC50: 9.60nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGF-induced EGFR phosphorylation at Tyr-residue in human HN5 cells preincubated for 24 hrs followed by EGF-stimulation and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM4583((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human His6-tagged EGFR cytoplasmic domain (645 to 1186 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508276(CHEMBL4464237)
Affinity DataIC50: 12nMAssay Description:Inhibition of VEGFR2 (unknown origin) using FAM-labelled peptide as substrate measured after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508271(CHEMBL4539051)
Affinity DataIC50: 14nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human GST-fused HER2 kinase domain expressed in baculovirus expression system measured after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 15nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM4779(cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL3196...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human A431 cell-derived EGFR using polyglutamic acid/tyrosine as substrate incubated for 10 mins followed by [32P]ATP addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508277(CHEMBL4548316)
Affinity DataIC50: 17nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 22nMAssay Description:Inhibition of B-Raf (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL29197 | N-(3-bromophenyl)-6,7-dimethoxyquina...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human A431 cell-derived EGFR using Lys-His-Lys-LysLeu-Ala-Glu-Gly-Ser-Ala-Tyr472-Glu-Glu-Val as substrate measured after 10 mins in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508277(CHEMBL4548316)
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508273(CHEMBL4589270)
Affinity DataIC50: 31nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 31nMAssay Description:Inhibition of B-Raf (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508278(CHEMBL4578561)
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant human His6-tagged EGFR cytoplasmic domain (645 to 1186 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM31090((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...)
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant human His6-tagged EGFR cytoplasmic domain (645 to 1186 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508275(CHEMBL4453846)
Affinity DataIC50: 42nMAssay Description:Inhibition of VEGFR2 (unknown origin) using FAM-labelled peptide as substrate measured after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508280(CHEMBL4590229)
Affinity DataIC50: 45nMAssay Description:Inhibition of VEGFR2 (unknown origin) using FAM-labelled peptide as substrate measured after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50: 46nMAssay Description:Inhibition of human GST-fused HER2 kinase domain expressed in baculovirus expression system measured after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508271(CHEMBL4539051)
Affinity DataIC50: 52nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508279(CHEMBL4578466)
Affinity DataIC50: 59nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508281(CHEMBL4531086)
Affinity DataIC50: 78nMAssay Description:Inhibition of VEGFR2 (unknown origin) using FAM-labelled peptide as substrate measured after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508279(CHEMBL4578466)
Affinity DataIC50: 92nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508272(CHEMBL4467277)
Affinity DataIC50: 178nMAssay Description:Inhibition of HDAC1 (unknown origin) using HDAC substrate by AFC probe based immunoprecipitation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM4583((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)
Affinity DataIC50: 301nMAssay Description:Inhibition of recombinant human His6-tagged HER2 cytoplasmic domain (676 to 1245 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50508278(CHEMBL4578561)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed