Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50007294
TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM332539(US10196365, Compound 4 | (E)-N-(4-(3-chloro-4-fluo...)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of recombinant human GST-tagged EGFR catalytic domain (668 to 1210 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM332536(US10196365, Compound 1 | (E)-N-(4-(3-chloro-4-fluo...)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of recombinant human GST-tagged EGFR catalytic domain (668 to 1210 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM332537(US10196365, Compound 2 | (R,E)-N-(4-(3-chloro-4-fl...)
Affinity DataIC50: 0.940nMAssay Description:Inhibition of recombinant human GST-tagged EGFR catalytic domain (668 to 1210 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 0.960nMAssay Description:Inhibition of recombinant human GST-tagged EGFR catalytic domain (668 to 1210 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM332541(US10196365, Compound 6 | (E)-N-(4-(3-chloro-4-fluo...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human GST-tagged EGFR catalytic domain (668 to 1210 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50508283(CHEMBL4591886)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human GST-tagged EGFR catalytic domain (668 to 1210 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM332538(US10196365, Compound 3 | (S,E)-N-(4-(3-chloro-4-fl...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant human GST-tagged EGFR catalytic domain (668 to 1210 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM332540(US10196365, Compound 5 | (E)-N-(4-(3-chloro-4-fluo...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant human GST-tagged EGFR catalytic domain (668 to 1210 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50508283(CHEMBL4591886)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human His-tagged HER2 catalytic domain (676 to 1255 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM332536(US10196365, Compound 1 | (E)-N-(4-(3-chloro-4-fluo...)
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant human His-tagged HER2 catalytic domain (676 to 1255 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM332539(US10196365, Compound 4 | (E)-N-(4-(3-chloro-4-fluo...)
Affinity DataIC50: 42nMAssay Description:Inhibition of recombinant human His-tagged HER2 catalytic domain (676 to 1255 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 74nMAssay Description:Inhibition of recombinant human His-tagged HER2 catalytic domain (676 to 1255 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM332541(US10196365, Compound 6 | (E)-N-(4-(3-chloro-4-fluo...)
Affinity DataIC50: 84nMAssay Description:Inhibition of recombinant human His-tagged HER2 catalytic domain (676 to 1255 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM332540(US10196365, Compound 5 | (E)-N-(4-(3-chloro-4-fluo...)
Affinity DataIC50: 132nMAssay Description:Inhibition of recombinant human His-tagged HER2 catalytic domain (676 to 1255 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM332537(US10196365, Compound 2 | (R,E)-N-(4-(3-chloro-4-fl...)
Affinity DataIC50: 148nMAssay Description:Inhibition of recombinant human His-tagged HER2 catalytic domain (676 to 1255 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM332543(US10196365, Compound 11 | (E) N (4 (4 (3 fluoroben...)
Affinity DataIC50: 154nMAssay Description:Inhibition of recombinant human GST-tagged EGFR catalytic domain (668 to 1210 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM332543(US10196365, Compound 11 | (E) N (4 (4 (3 fluoroben...)
Affinity DataIC50: 262nMAssay Description:Inhibition of recombinant human His-tagged HER2 catalytic domain (676 to 1255 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM332538(US10196365, Compound 3 | (S,E)-N-(4-(3-chloro-4-fl...)
Affinity DataIC50: 482nMAssay Description:Inhibition of recombinant human His-tagged HER2 catalytic domain (676 to 1255 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed