Compile Data Set for Download or QSAR
Report error Found 502 Enz. Inhib. hit(s) with all data for entry = 50009566
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529959(CHEMBL4551786)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as increased in calcium activated photo protein aequorin level...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529959(CHEMBL4551786)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as increased in calcium activated photo protein aequorin level...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50105834(CHEMBL3597594)
Affinity DataIC50: 0.800nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50105834(CHEMBL3597594)
Affinity DataIC50: 0.800nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529958(CHEMBL4472693)
Affinity DataIC50: 2.5nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529958(CHEMBL4472693)
Affinity DataIC50: 2.5nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529965(CHEMBL4441707)
Affinity DataIC50: 3.30nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529965(CHEMBL4441707)
Affinity DataIC50: 3.30nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529959(CHEMBL4551786)
Affinity DataIC50: 4.10nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529959(CHEMBL4551786)
Affinity DataIC50: 4.10nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529954(CHEMBL4446275)
Affinity DataIC50: 5.10nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529954(CHEMBL4446275)
Affinity DataIC50: 5.10nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529974(CHEMBL4544729)
Affinity DataIC50: 6nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529974(CHEMBL4544729)
Affinity DataIC50: 6nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529989(CHEMBL4542890)
Affinity DataIC50: 6.40nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529989(CHEMBL4542890)
Affinity DataIC50: 6.40nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529972(CHEMBL4472416)
Affinity DataIC50: 6.5nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529972(CHEMBL4472416)
Affinity DataIC50: 6.5nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-phenylethynyl-pyridine | CHEMBL66654 | ...)
Affinity DataIC50: 11nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-phenylethynyl-pyridine | CHEMBL66654 | ...)
Affinity DataIC50: 11nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529971(CHEMBL4464022)
Affinity DataIC50: 15nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529971(CHEMBL4464022)
Affinity DataIC50: 15nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529955(CHEMBL4475143)
Affinity DataIC50: 19nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529955(CHEMBL4475143)
Affinity DataIC50: 19nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529956(CHEMBL4551238)
Affinity DataIC50: 23nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529956(CHEMBL4551238)
Affinity DataIC50: 23nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529987(CHEMBL4448788)
Affinity DataIC50: 27nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529987(CHEMBL4448788)
Affinity DataIC50: 27nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529983(CHEMBL4441964)
Affinity DataIC50: 29nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529983(CHEMBL4441964)
Affinity DataIC50: 29nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529984(CHEMBL4448804)
Affinity DataIC50: 34nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529984(CHEMBL4448804)
Affinity DataIC50: 34nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataIC50: 36nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataIC50: 36nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529976(CHEMBL4452522)
Affinity DataIC50: 44nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529976(CHEMBL4452522)
Affinity DataIC50: 44nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50122758(3-(2-(2-methylthiazol-4-yl)ethynyl)pyridine | 3-[(...)
Affinity DataIC50: 47nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50122758(3-(2-(2-methylthiazol-4-yl)ethynyl)pyridine | 3-[(...)
Affinity DataIC50: 47nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529980(CHEMBL4535926)
Affinity DataIC50: 49nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529980(CHEMBL4535926)
Affinity DataIC50: 49nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529990(CHEMBL4456792)
Affinity DataIC50: 50nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529990(CHEMBL4456792)
Affinity DataIC50: 50nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529962(CHEMBL4539036)
Affinity DataIC50: 53nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529962(CHEMBL4539036)
Affinity DataIC50: 53nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529961(CHEMBL4483689)
Affinity DataIC50: 67nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529961(CHEMBL4483689)
Affinity DataIC50: 67nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529991(CHEMBL4567923)
Affinity DataIC50: 88nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529991(CHEMBL4567923)
Affinity DataIC50: 88nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529960(CHEMBL4520868)
Affinity DataIC50: 90nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50529960(CHEMBL4520868)
Affinity DataIC50: 90nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
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