Compile Data Set for Download or QSAR
Report error Found 89 Enz. Inhib. hit(s) with all data for entry = 50006848
TargetAngiotensin-converting enzyme(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human ACE using Mca-BK2 as substrate preincubated for 10 mins followed by fluorogenic substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503875(CHEMBL4435800)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503883(CHEMBL4443691)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503902(CHEMBL4588688)
Affinity DataKi:  0.794nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503895(CHEMBL4465325)
Affinity DataIC50: 1nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503881(CHEMBL4469350)
Affinity DataIC50: 1nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503886(CHEMBL4456519)
Affinity DataIC50: 1nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503884(CHEMBL4547120)
Affinity DataIC50: 1nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503894(CHEMBL4591218)
Affinity DataKi:  1.30nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503896(CHEMBL4445778)
Affinity DataKi:  1.30nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503875(CHEMBL4435800)
Affinity DataKi:  1.30nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50: 2nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503885(CHEMBL4438878)
Affinity DataKi:  2.5nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503907(CHEMBL4449166)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503873(CHEMBL4447138)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503897(CHEMBL4474870)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503893(CHEMBL4454778)
Affinity DataKi:  5nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503897(CHEMBL4474870)
Affinity DataKi:  5nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503887(CHEMBL4543532)
Affinity DataKi:  5nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM82258(NSC_3961 | CAS_114798-26-4 | Losartan)
Affinity DataKi:  5nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503900(CHEMBL4456544)
Affinity DataKi:  6.30nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503895(CHEMBL4465325)
Affinity DataKi:  6.30nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503903(CHEMBL4437331)
Affinity DataKi:  7.90nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503904(CHEMBL4440944)
Affinity DataKi:  10nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503888(CHEMBL4470834)
Affinity DataKi:  10nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503902(CHEMBL4588688)
Affinity DataIC50: 16nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503887(CHEMBL4543532)
Affinity DataIC50: 16nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503889(CHEMBL4464191)
Affinity DataKi:  16nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503898(CHEMBL4558883)
Affinity DataKi:  16nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503886(CHEMBL4456519)
Affinity DataKi:  20nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503901(CHEMBL4458466)
Affinity DataIC50: 20nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503872(CHEMBL4459070)
Affinity DataKi:  32nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503894(CHEMBL4591218)
Affinity DataIC50: 32nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503901(CHEMBL4458466)
Affinity DataKi:  32nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503884(CHEMBL4547120)
Affinity DataKi:  32nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503877(CHEMBL4535903)
Affinity DataKi:  40nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503873(CHEMBL4447138)
Affinity DataKi:  40nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503878(CHEMBL4463203)
Affinity DataIC50: 40nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503906(CHEMBL4463575)
Affinity DataIC50: 40nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503885(CHEMBL4438878)
Affinity DataIC50: 50nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503882(CHEMBL4535256)
Affinity DataKi:  50nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503906(CHEMBL4463575)
Affinity DataKi:  50nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503880(CHEMBL4552884)
Affinity DataKi:  50nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503889(CHEMBL4464191)
Affinity DataIC50: 63nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503877(CHEMBL4535903)
Affinity DataIC50: 63nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503881(CHEMBL4469350)
Affinity DataKi:  63nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503896(CHEMBL4445778)
Affinity DataIC50: 79nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503892(CHEMBL4438435)
Affinity DataKi:  79nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503876(CHEMBL4579452)
Affinity DataKi:  79nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
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