Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50008692
LigandPNGBDBM50521329(CHEMBL4468037)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at STING in human THP1 cells assessed as stimulation of IFNbeta production measured after 5 hrs by Alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521331(CHEMBL4557373 | US11311528, Ex. 1-85)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at STING in human THP1 cells assessed as stimulation of IFNbeta production measured after 5 hrs by Alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50521324(CHEMBL4554395 | US11311528, Ex. 1-77)
Affinity DataIC50: 41nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521331(CHEMBL4557373 | US11311528, Ex. 1-85)
Affinity DataIC50: 68nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50521329(CHEMBL4468037)
Affinity DataIC50: 84nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521332(CHEMBL4524926)
Affinity DataIC50: 106nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521330(CHEMBL4450597 | US11311528, Ex. 1-76)
Affinity DataIC50: 384nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521335(CHEMBL4588504 | US11311528, Ex. 1-78)
Affinity DataIC50: 670nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521326(CHEMBL4538028)
Affinity DataIC50: 2.70E+3nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521325(CHEMBL4444823)
Affinity DataIC50: 7.30E+3nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50521331(CHEMBL4557373 | US11311528, Ex. 1-85)
Affinity DataIC50: 1.10E+4nMAssay Description:Antagonist activity at STING in human THP1 cells assessed as inhibition of cGAMP-induced IFNbeta production pretreated for 6 hrs followed by cGAMP ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50521329(CHEMBL4468037)
Affinity DataIC50: 1.15E+4nMAssay Description:Antagonist activity at STING in human THP1 cells assessed as inhibition of cGAMP-induced IFNbeta production pretreated for 6 hrs followed by cGAMP ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521327(CHEMBL4442747)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521328(CHEMBL4454076)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521323(CHEMBL4443618)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521333(CHEMBL4459747)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521334(CHEMBL4472138)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed