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Report error Found 119 Enz. Inhib. hit(s) with all data for entry = 50022588
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataKd:  450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataKd:  18nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataKd:  36nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 21nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 21nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 26nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM657583(US20240083857, Example 262 | N-[1-(5-{2-[(dimethyl...)
Affinity DataIC50: 40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657571(6,7-dimethoxy-2-methyl-N-[1-(5-{2-[(methylamino)me...)
Affinity DataIC50: 41nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657618(2-{[2-(5-{1-[(6,7-dimethoxy-2-methylquinazolin-4-y...)
Affinity DataIC50: 46nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657619(2-{[2-(5-{1-[(6,7-dimethoxy-2-methylquinazolin-4-y...)
Affinity DataIC50: 47nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652970(CHEMBL5687017)
Affinity DataIC50: 51nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 52nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 53nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM657688(N-[1-(5-{2-[(ethylamino)methyl]phenyl}thiophen-2-y...)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 61nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657638(N-[1-{5-[2-(azetidin-1-ylmethyl)phenyl]thiophen-2-...)
Affinity DataIC50: 76nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657573(N-[1-{5-[2-(aminomethyl)phenyl]thiophen-2-yl}ethyl...)
Affinity DataIC50: 80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 91nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 94nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657687(N-[1-(5-{2-[(butylamino)methyl]phenyl}thiophen-2-y...)
Affinity DataIC50: 98nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657690(6,7-dimethoxy-N-{1-[5-(2-{[(2-methoxyethyl)amino]m...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657341(6,7-dimethoxy-2-methyl-N-[(1R)-1-(naphthalen-1-yl)...)
Affinity DataIC50: 130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)
Affinity DataIC50: 140nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 150nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM657512(N-[(1R)-1-(3-bromophenyl)ethyl]-6,7-dimethoxy-2-me...)
Affinity DataIC50: 170nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657609(N-[1-(5-{2-[(diethylamino)methyl]phenyl}thiophen-2...)
Affinity DataIC50: 170nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 180nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)
Affinity DataIC50: 190nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 190nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657680(N-[1-(5-{2-[1-aminoethyl]phenyl}thiophen-2-yl)ethy...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM657681(N-[1-(5-{2-[1-aminoethyl]phenyl}thiophen-2-yl)ethy...)
Affinity DataIC50: 230nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)
Affinity DataIC50: 260nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 260nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657565([2-(5-{1-[(6,7-dimethoxy-2-methylquinazolin-4-yl)a...)
Affinity DataIC50: 280nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50: 320nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50: 340nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 360nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50: 400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM657540(US20240083857, Example 219 | N-{1-[5-(6,7-dihydro-...)
Affinity DataIC50: 400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657774(N-[1-{5-[2-(2-aminopropan-2-yl)phenyl]thiophen-2-y...)
Affinity DataIC50: 400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657643(N-[1-(5-{2-[(3-fluoroazetidin-1-yl)methyl]phenyl}t...)
Affinity DataIC50: 410nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 410nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 410nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)
Affinity DataIC50: 450nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657540(US20240083857, Example 219 | N-{1-[5-(6,7-dihydro-...)
Affinity DataIC50: 450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657686(N-[1-(5-{2-[(benzylamino)methyl]phenyl}thiophen-2-...)
Affinity DataIC50: 470nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)
Affinity DataIC50: 470nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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