Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50009756
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531902(CHEMBL4569405)
Affinity DataKi:  32nMAssay Description:Competitive inhibition of recombinant human PTP1B expressed in Escherichia coli using varying levels of p-nitrophenol as substrate by Lineweaver-burk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531902(CHEMBL4569405)
Affinity DataIC50: 79nMAssay Description:Inhibition of recombinant human PTP1B expressed in Escherichia coli using p-nitrophenol as substrate preincubated with substrate for 5 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531901(CHEMBL4540813)
Affinity DataKi:  140nMAssay Description:Competitive inhibition of recombinant human PTP1B expressed in Escherichia coli using varying levels of p-nitrophenol as substrate by Lineweaver-burk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531902(CHEMBL4569405)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MEG1 catalytic domain (637 to 926 residues) expressed in Escherichia coli using p-nitrophenol a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531902(CHEMBL4569405)
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged TCPTP catalytic domain (2 to 315 residues) expressed in Escherichia coli using p-nitrophenol as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531901(CHEMBL4540813)
Affinity DataIC50: 380nMAssay Description:Inhibition of recombinant human PTP1B expressed in Escherichia coli using p-nitrophenol as substrate preincubated with substrate for 5 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 9(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531902(CHEMBL4569405)
Affinity DataIC50: 410nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MEG2 catalytic domain (285 to 593 residues) expressed in Escherichia coli using p-nitrophenol a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531902(CHEMBL4569405)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human SHP2 expressed in Escherichia coli using p-nitrophenol as substrate preincubated with substrate for 5 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 9(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531903(CHEMBL4530344)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MEG2 catalytic domain (285 to 593 residues) expressed in Escherichia coli using p-nitrophenol a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531903(CHEMBL4530344)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant human PTP1B expressed in Escherichia coli using p-nitrophenol as substrate preincubated with substrate for 5 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531901(CHEMBL4540813)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of recombinant human SHP2 expressed in Escherichia coli using p-nitrophenol as substrate preincubated with substrate for 5 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531903(CHEMBL4530344)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of recombinant human SHP2 expressed in Escherichia coli using p-nitrophenol as substrate preincubated with substrate for 5 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531901(CHEMBL4540813)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MEG1 catalytic domain (637 to 926 residues) expressed in Escherichia coli using p-nitrophenol a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 9(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531901(CHEMBL4540813)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MEG2 catalytic domain (285 to 593 residues) expressed in Escherichia coli using p-nitrophenol a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531901(CHEMBL4540813)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged TCPTP catalytic domain (2 to 315 residues) expressed in Escherichia coli using p-nitrophenol as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531903(CHEMBL4530344)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged TCPTP catalytic domain (2 to 315 residues) expressed in Escherichia coli using p-nitrophenol as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531903(CHEMBL4530344)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MEG1 catalytic domain (637 to 926 residues) expressed in Escherichia coli using p-nitrophenol a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed