Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50010273
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537001(CHEMBL4520937)
Affinity DataIC50: 4.20nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261864(2-(9-Ethyl-9H-carbazol-3-yl)-4-fluoro-1-(2-methoxy...)
Affinity DataIC50: 4.30nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261893(2-(6-Chloro-9-ethyl-9H-carbazol-3-yl)-1-(2-methoxy...)
Affinity DataIC50: 4.40nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537002(CHEMBL4483026)
Affinity DataIC50: 4.70nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261894(2-(8-Chloro-9-ethyl-9H-carbazol-3-yl)-1-(2-methoxy...)
Affinity DataIC50: 5.20nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261795(3-[2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)...)
Affinity DataIC50: 6.10nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261794(9-Ethyl-3-[1-(2-methoxyethyl)-5-(1H-tetrazol-5-yl)...)
Affinity DataIC50: 6.80nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261884(2-(9-Ethyl-9H-carbazol-3-yl)-1-(tetrahydrofuran-2-...)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537004(CHEMBL4584103)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261892(2-(9-Ethyl-6-methyl-9H-carbazol-3-yl)-1-(2-methoxy...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261766(N-[(3-Chlorophenyl)sulphonyl]-2-(9-ethyl-9H-carbaz...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537016(CHEMBL4563081)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537008(CHEMBL4531968)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537003(CHEMBL4548032)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261867(1-(2-Cyclopropylethyl)-2-(9-ethyl-9H-carbazol-3-yl...)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537005(CHEMBL4587481)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261855(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-4-...)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537015(CHEMBL4571025)
Affinity DataIC50: 34nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261783(1-(Cyclopropylmethyl)-2-(9-methyl-9H-carbazol-3-yl...)
Affinity DataIC50: 34nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261863(2-(9-Ethyl-9H-carbazol-3-yl)-6-fluoro-1-(2-methoxy...)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261856(5-[2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)...)
Affinity DataIC50: 44nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261883(2-(9-Ethyl-9H-carbazol-3-yl)-1-(oxetan-2-ylmethyl)...)
Affinity DataIC50: 52nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537013(CHEMBL4554923)
Affinity DataIC50: 55nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261871(1-(Cyclopropylmethyl)-2-(9-propyl-9H-carbazol-3-yl...)
Affinity DataIC50: 63nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537010(CHEMBL4536877)
Affinity DataIC50: 66nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537002(CHEMBL4483026)
Affinity DataIC50: 81nMAssay Description:Antagonist activity at mouse EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261821(1-[2-(Dimethylamino)ethyl]-2-(9-ethyl-9H-carbazol-...)
Affinity DataIC50: 83nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537004(CHEMBL4584103)
Affinity DataIC50: 113nMAssay Description:Antagonist activity at mouse EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261831(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-1H...)
Affinity DataIC50: 134nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537006(CHEMBL4521321)
Affinity DataIC50: 148nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261850(2-(9-Ethyl-9H-carbazol-3-yl)-1-(3-methoxypropyl)-1...)
Affinity DataIC50: 158nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261844(2-(9-Ethyl-9H-carbazol-3-y1)-1-methyl-1 H-benzimid...)
Affinity DataIC50: 166nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537012(CHEMBL4581855)
Affinity DataIC50: 222nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261876(2-[9-(Cyclobutylmethyl)-9H-carbazol-3-yl]-1-(cyclo...)
Affinity DataIC50: 257nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537011(CHEMBL4593176)
Affinity DataIC50: 286nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537009(CHEMBL4524507)
Affinity DataIC50: 366nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261861(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-6-...)
Affinity DataIC50: 612nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261843(2-(9-Ethyl-9H-carbazol-3-yl)-1-isopropyl-1H-benzim...)
Affinity DataIC50: 733nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537007(CHEMBL4527730)
Affinity DataIC50: 751nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537014(CHEMBL4553842)
Affinity DataIC50: 1.42E+3nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50537000(CHEMBL4591445)
Affinity DataIC50: 3.12E+3nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed