Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50009208
TargetHistone-lysine N-methyltransferase SETD7(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50075073(CHEMBL3414622)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant full-length human SETD7 (1 to 366 residues) expressed in Escherichia coli BL21 (DE3) using [3H]-SAM-fused biotinylated pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EZH2(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50075054(CHEMBL3414574)
Affinity DataIC50: 13nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin) using dimethylated H3K27 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 15nMAssay Description:Inhibition of SMYD2 (unknown origin) using [3H]-p53 (361 to 380 residues) as substrate after 1 hr in presence of [3H]-SAM by scintillation proximity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50075054(CHEMBL3414574)
Affinity DataIC50: 15nMAssay Description:Inhibition of EZH2 (unknown origin) using unmethylated H3K27 (21 to 44 residues) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50526154(CHEMBL4460191)
Affinity DataIC50: 100nMAssay Description:Inhibition of DOT1L in human THP1 cells assessed as reduction in H3K79 methylation measured after 7 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50396029(CHEMBL1222849)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of GST-tagged EHMT2 (unknown origin) using biotinylated-H3 peptide as substrate preincubated for 1 hr followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50315537(chaetocin | CHEMBL1089316)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of GST-tagged EHMT2 (unknown origin) using biotinylated-H3 peptide as substrate preincubated for 1 hr followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of SETD8 (unknown origin) using biotinylated-H3 peptide as substrate measured after 1 hr in presence of [3H]-SAM by scintillation proximit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50526154(CHEMBL4460191)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CARM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50526154(CHEMBL4460191)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50526154(CHEMBL4460191)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EHMT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50526154(CHEMBL4460191)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed