Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50009219
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526262(CHEMBL4439989)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526257(CHEMBL4555282)
Affinity DataIC50: 28nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526264(CHEMBL4452694)
Affinity DataIC50: 32nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526258(CHEMBL4455995)
Affinity DataIC50: 39nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)
Affinity DataIC50: 40nMAssay Description:Inhibition of GAT-1 in rat brain homogenate assessed as decrease in [3H]GABA uptake preincubated for 8 mins followed by [3H]GABA addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526265(CHEMBL4520656)
Affinity DataIC50: 56nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526261(CHEMBL4565664)
Affinity DataIC50: 60nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526259(CHEMBL4565745)
Affinity DataIC50: 66nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataIC50: 70nMAssay Description:Inhibition of GAT-1 in rat brain homogenate assessed as decrease in [3H]GABA uptake preincubated for 8 mins followed by [3H]GABA addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50426074(CHEMBL2315957)
Affinity DataIC50: 80nMAssay Description:Inhibition of GAT-1 in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526263(CHEMBL4475547)
Affinity DataIC50: 85nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526260(CHEMBL4554639)
Affinity DataIC50: 102nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50003634(1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxyli...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526256(CHEMBL4551183)
Affinity DataIC50: 170nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)
Affinity DataIC50: 5.96E+3nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50003624(Nipecotic | Piperidine-3-carboxylic acid(nipecotic...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM90787(SMR000326834 | cid_11957555 | GUVACINE | MLS000859...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526256(CHEMBL4551183)
Affinity DataIC50: 1.78E+4nMAssay Description:Inhibition of mouse GAT-2 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526256(CHEMBL4551183)
Affinity DataIC50: 3.24E+4nMAssay Description:Inhibition of mouse GAT-4 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526256(CHEMBL4551183)
Affinity DataIC50: 3.31E+4nMAssay Description:Inhibition of mouse GAT-3 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526257(CHEMBL4555282)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of mouse GAT-2 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526261(CHEMBL4565664)
Affinity DataIC50: 4.27E+4nMAssay Description:Inhibition of mouse GAT-2 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526258(CHEMBL4455995)
Affinity DataIC50: 4.57E+4nMAssay Description:Inhibition of mouse GAT-2 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526261(CHEMBL4565664)
Affinity DataIC50: 5.75E+4nMAssay Description:Inhibition of mouse GAT-3 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526261(CHEMBL4565664)
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of mouse GAT-4 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526258(CHEMBL4455995)
Affinity DataIC50: 6.61E+4nMAssay Description:Inhibition of mouse GAT-3 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526258(CHEMBL4455995)
Affinity DataIC50: 7.08E+4nMAssay Description:Inhibition of mouse GAT-4 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526257(CHEMBL4555282)
Affinity DataIC50: 7.24E+4nMAssay Description:Inhibition of mouse GAT-4 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526257(CHEMBL4555282)
Affinity DataIC50: 9.12E+4nMAssay Description:Inhibition of mouse GAT-3 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 1.16E+5nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526264(CHEMBL4452694)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to mouse GAT-1 expressed in HEK293 cells after 4 hrs in presence of NO711 by LC-ESI-MS/ms analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526265(CHEMBL4520656)
Affinity DataKi:  4.5nMAssay Description:Binding affinity to mouse GAT-1 expressed in HEK293 cells after 4 hrs in presence of NO711 by LC-ESI-MS/ms analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526262(CHEMBL4439989)
Affinity DataKi:  5.10nMAssay Description:Binding affinity to mouse GAT-1 expressed in HEK293 cells after 4 hrs in presence of NO711 by LC-ESI-MS/ms analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526261(CHEMBL4565664)
Affinity DataKi:  5.90nMAssay Description:Binding affinity to mouse GAT-1 expressed in HEK293 cells after 4 hrs in presence of NO711 by LC-ESI-MS/ms analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526260(CHEMBL4554639)
Affinity DataKi:  5.90nMAssay Description:Binding affinity to mouse GAT-1 expressed in HEK293 cells after 4 hrs in presence of NO711 by LC-ESI-MS/ms analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526259(CHEMBL4565745)
Affinity DataKi:  10nMAssay Description:Binding affinity to mouse GAT-1 expressed in HEK293 cells after 4 hrs in presence of NO711 by LC-ESI-MS/ms analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526258(CHEMBL4455995)
Affinity DataKi:  10nMAssay Description:Binding affinity to mouse GAT-1 expressed in HEK293 cells after 4 hrs in presence of NO711 by LC-ESI-MS/ms analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526257(CHEMBL4555282)
Affinity DataKi:  12nMAssay Description:Binding affinity to mouse GAT-1 expressed in HEK293 cells after 4 hrs in presence of NO711 by LC-ESI-MS/ms analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526263(CHEMBL4475547)
Affinity DataKi:  14nMAssay Description:Binding affinity to mouse GAT-1 expressed in HEK293 cells after 4 hrs in presence of NO711 by LC-ESI-MS/ms analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50526256(CHEMBL4551183)
Affinity DataKi:  17nMAssay Description:Binding affinity to mouse GAT-1 expressed in HEK293 cells after 4 hrs in presence of NO711 by LC-ESI-MS/ms analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataKi:  55nMAssay Description:Binding affinity to mouse GAT-1 expressed in HEK293 cells after 4 hrs in presence of NO711 by LC-ESI-MS/ms analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed