Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50010117
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50: 15nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535309(CHEMBL4582195)
Affinity DataIC50: 27nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM26474(GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...)
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535325(CHEMBL4437943)
Affinity DataIC50: 54nMAssay Description:Inhibition of human HER2 in human A549 cells by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 57nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (695 to end) expressed in baculovirus infected Sf9 cells using ATP as substrate after 40 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535314(CHEMBL4437803)
Affinity DataIC50: 64nMAssay Description:Inhibition of human HER2 in human A549 cells by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 64nMAssay Description:Inhibition of human HER2 in human A549 cells by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535325(CHEMBL4437943)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (695 to end) expressed in baculovirus infected Sf9 cells using ATP as substrate after 40 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 80nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535309(CHEMBL4582195)
Affinity DataIC50: 84nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (695 to end) expressed in baculovirus infected Sf9 cells using ATP as substrate after 40 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535314(CHEMBL4437803)
Affinity DataIC50: 87nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 90nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535325(CHEMBL4437943)
Affinity DataIC50: 94nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535330(CHEMBL4466088)
Affinity DataIC50: 96nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535323(CHEMBL4543044)
Affinity DataIC50: 96nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535318(CHEMBL4584717)
Affinity DataIC50: 100nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535309(CHEMBL4582195)
Affinity DataIC50: 104nMAssay Description:Inhibition of human HER2 in human A549 cells by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535324(CHEMBL4443510)
Affinity DataIC50: 113nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535327(CHEMBL4521454)
Affinity DataIC50: 115nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535313(CHEMBL4536372)
Affinity DataIC50: 120nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535314(CHEMBL4437803)
Affinity DataIC50: 147nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (695 to end) expressed in baculovirus infected Sf9 cells using ATP as substrate after 40 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535321(CHEMBL4513911)
Affinity DataIC50: 160nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535316(CHEMBL4558158)
Affinity DataIC50: 160nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 180nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535326(CHEMBL4529255)
Affinity DataIC50: 200nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535319(CHEMBL4449758)
Affinity DataIC50: 200nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535320(CHEMBL4467322)
Affinity DataIC50: 221nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535322(CHEMBL4570460)
Affinity DataIC50: 286nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535331(CHEMBL4465496)
Affinity DataIC50: 302nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535310(CHEMBL4436488)
Affinity DataIC50: 319nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535312(CHEMBL4469407)
Affinity DataIC50: 396nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535317(CHEMBL4517008)
Affinity DataIC50: 650nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535315(CHEMBL4516917)
Affinity DataIC50: 753nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535311(CHEMBL4438721)
Affinity DataIC50: 772nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535329(CHEMBL4440653)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of human MER incubated for 90 mins by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535328(CHEMBL4567879)
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535314(CHEMBL4437803)
Affinity DataIC50: 2.63E+3nMAssay Description:Inhibition of human MER incubated for 90 mins by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535325(CHEMBL4437943)
Affinity DataIC50: 3.12E+3nMAssay Description:Inhibition of human MER incubated for 90 mins by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535309(CHEMBL4582195)
Affinity DataIC50: 3.95E+3nMAssay Description:Inhibition of human MER incubated for 90 mins by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 5.75E+3nMAssay Description:Inhibition of human c-MET incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535314(CHEMBL4437803)
Affinity DataIC50: 6.22E+3nMAssay Description:Inhibition of human c-MET incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535309(CHEMBL4582195)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of human c-MET incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535325(CHEMBL4437943)
Affinity DataIC50: 1.79E+4nMAssay Description:Inhibition of human c-MET incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed