Compile Data Set for Download or QSAR
Report error Found 204 Enz. Inhib. hit(s) with all data for entry = 50007475
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409484(1-(Azetidin-1-yl)-2-[6-(4-fluoro-3-methyl-phenyl)p...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409560(2-[6-(5-Chloro-4-methyl-2-thienyl)pyrrolo[3,2-b]py...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50509848(CHEMBL4547576)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409128(2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...)
Affinity DataKi:  7.70nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409482(1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluoro-3-methyl-...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409275(2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409568(N,N-Dimethyl-2-[6-(m-tolyl)pyrrolo[3,2-b]pyridin-1...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436689(US10617676, Example 20 | N-Cyclopropyl-2-[2-oxo-6-...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]Ro25-6981 from rat GluN2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409569(N,N-Dimethyl-2-[6-[3-(trifluoromethyl)phenyl]pyrro...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409264(1-(Azetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409514(2-[6-(3,4-Difluorophenyl)pyrrolo[3,2-b]pyridin-1-y...)
Affinity DataIC50: 15nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409572(N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]p...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409484(1-(Azetidin-1-yl)-2-[6-(4-fluoro-3-methyl-phenyl)p...)
Affinity DataIC50: 16nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409602(2-[6-(3-Chloro-4-fluoro-phenyl)pyrrolo[3,2-b]pyrid...)
Affinity DataIC50: 17nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50509848(CHEMBL4547576)
Affinity DataIC50: 18nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409560(2-[6-(5-Chloro-4-methyl-2-thienyl)pyrrolo[3,2-b]py...)
Affinity DataIC50: 21nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436689(US10617676, Example 20 | N-Cyclopropyl-2-[2-oxo-6-...)
Affinity DataIC50: 22nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50509850(CHEMBL4451514)
Affinity DataIC50: 23nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409602(2-[6-(3-Chloro-4-fluoro-phenyl)pyrrolo[3,2-b]pyrid...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409275(2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...)
Affinity DataIC50: 25nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409513(2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50509851(CHEMBL4529810)
Affinity DataIC50: 29nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409482(1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluoro-3-methyl-...)
Affinity DataIC50: 30nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409513(2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...)
Affinity DataIC50: 32nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409568(N,N-Dimethyl-2-[6-(m-tolyl)pyrrolo[3,2-b]pyridin-1...)
Affinity DataIC50: 33nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409301(2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409521(N,N-Dimethyl-2-[6-(5-methyl-2-thienyl)pyrrolo[3,2-...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409264(1-(Azetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 37nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409486(N-Cyclopropyl-2-[6-[3-(trifluoromethyl)phenyl]pyrr...)
Affinity DataIC50: 38nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409563(2-[6-(3-Chlorophenyl)pyrrolo[3,2-b]pyridin-1-yl]-N...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409128(2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...)
Affinity DataIC50: 41nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409563(2-[6-(3-Chlorophenyl)pyrrolo[3,2-b]pyridin-1-yl]-N...)
Affinity DataIC50: 44nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50509850(CHEMBL4451514)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409572(N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]p...)
Affinity DataIC50: 47nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50509849(CHEMBL4590530)
Affinity DataIC50: 47nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50509851(CHEMBL4529810)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409514(2-[6-(3,4-Difluorophenyl)pyrrolo[3,2-b]pyridin-1-y...)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409521(N,N-Dimethyl-2-[6-(5-methyl-2-thienyl)pyrrolo[3,2-...)
Affinity DataIC50: 54nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409279(6-(4-Fluoro-3-methyl-phenyl)-1-(2-pyridylmethyl)py...)
Affinity DataKi:  66nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409280((R/S)-6-(4-Fluoro-3-methyl-phenyl)-1-(tetrahydrofu...)
Affinity DataIC50: 67nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409280((R/S)-6-(4-Fluoro-3-methyl-phenyl)-1-(tetrahydrofu...)
Affinity DataKi:  75nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409352(5-[[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyri...)
Affinity DataKi:  78nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50509847(CHEMBL4467491)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409569(N,N-Dimethyl-2-[6-[3-(trifluoromethyl)phenyl]pyrro...)
Affinity DataIC50: 81nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50509849(CHEMBL4590530)
Affinity DataKi:  88nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409375(2-[[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyri...)
Affinity DataIC50: 91nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409486(N-Cyclopropyl-2-[6-[3-(trifluoromethyl)phenyl]pyrr...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409399((R/S)-1-Cyclopropyl-2-[6-(4-fluoro-3-methyl-phenyl...)
Affinity DataKi:  109nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409375(2-[[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyri...)
Affinity DataKi:  117nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409575(N,N-Dimethyl-2-[6-[6-(trifluoromethyl)-2-pyridyl]p...)
Affinity DataIC50: 145nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
Displayed 1 to 50 (of 204 total ) | Next | Last >>
Jump to: