Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50008979
TargetProstaglandin G/H synthase 2(Mouse)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50218973(CHEMBL44001)
Affinity DataIC50: 8.32nMAssay Description:Inhibition of mouse COX-2 in LPS-induced mouse peritoneal macrophage assessed as reduction in PGE2 release incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPhospholipase A2(Honeybee)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524139(CHEMBL4467602)
Affinity DataIC50: 10nMAssay Description:Inhibition of bee venom phospholipase A2 preincubated for 1 hr followed by addition of phosphotidylcholine and 1-palmitoyl-2-(1-14C) palmitoyl furthe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPhospholipase A2(Honeybee)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524135(CHEMBL4570349)
Affinity DataIC50: 20nMAssay Description:Inhibition of bee venom phospholipase A2 preincubated for 1 hr followed by addition of phosphotidylcholine and 1-palmitoyl-2-(1-14C) palmitoyl furthe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPhospholipase A2(Honeybee)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524140(CHEMBL4447483)
Affinity DataIC50: 30nMAssay Description:Inhibition of bee venom phospholipase A2 preincubated for 1 hr followed by addition of phosphotidylcholine and 1-palmitoyl-2-(1-14C) palmitoyl furthe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50143486(N-Acetyl-4-[4-(4-methanesulfonyl-phenyl)-5-oxo-2,5...)
Affinity DataIC50: 50nMAssay Description:Inhibition of ovine COX2 assessed as reduction in PGF2alpha production incubated for 15 mins by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50218964(CHEMBL44223)
Affinity DataIC50: 132nMAssay Description:Inhibition of mouse COX-2 in LPS-induced mouse peritoneal macrophage assessed as reduction in PGE2 release incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50127652(1-(4-Methanesulfonyl-phenyl)-8-methyl-4,5-dihydro-...)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50127653(1-(4-Methanesulfonyl-phenyl)-4,5-dihydro-3aH-napht...)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Guinea pig)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50078688(3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl...)
Affinity DataIC50: 600nMAssay Description:Inhibition of COX2 in guinea pig blood assessed as reduction of LPS-induced PGE2 accumulation at 10 to 10000 nM preincubated with LPS followed by com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPhospholipase A2(Honeybee)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524136(CHEMBL4553594)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of bee venom phospholipase A2 preincubated for 1 hr followed by addition of phosphotidylcholine and 1-palmitoyl-2-(1-14C) palmitoyl furthe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50125626(5-Hydroxy-4-(4-methanesulfonyl-phenyl)-5-methyl-3-...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as reduction in PGE2 formation preincubated for 15 mins followed by addition of LPS and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetTyrosinase(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50219502(4-hydroxyphenyl beta-D-glucopyranoside | hydroquin...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of tyrosinase (unknown origin) assessed as reduction in melanin formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50125624(3-(4-Chloro-phenyl)-5-hydroxy-4-(4-methanesulfonyl...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as reduction in PGE2 formation preincubated for 15 mins followed by addition of LPS and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Rabbit)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50078688(3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of COX2 in rabbit whole blood assessed as reduction of LPS-induced PGE2 accumulation at 10 to 10000 nM preincubated with LPS followed by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPhospholipase A2(Honeybee)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524137(CHEMBL4452147)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of bee venom phospholipase A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50487746(CHEMBL2262593)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3alpha/beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50487746(CHEMBL2262593)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50487746(CHEMBL2262593)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK1/cyclinB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human COX2 expressed in CHO cells cells assessed as reduction in PGE2 releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human COX2 expressed in human osteosarcoma cells assessed as reduction in PGE2 releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosinase(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524138(CHEBI:74456 | CHEMBL3182150)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of tyrosinase (unknown origin) assessed as reduction in melanin formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed