Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 50006997
TargetSonic hedgehog protein(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50249181(N-(4-chlorobenzyl)-2-((2R,6S,E)-5,12-dioxo-2-pheny...)
Affinity DataKd:  3.10E+3nMAssay Description:Binding affinity to N-terminal sonic hedgehog (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProtein-cysteine N-palmitoyltransferase HHAT(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50505253(CHEMBL4284857)
Affinity DataIC50: 200nMAssay Description:Inhibition of 3C-FLAG/His8-tagged human HHAT expressed in HEK293 cells assessed as reduction in enzyme-mediated sonic hedgehog (1 to 11 residues) pal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProtein-cysteine N-palmitoyltransferase HHAT(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50505254(CHEMBL3133036)
Affinity DataIC50: 850nMAssay Description:Inhibition of HA/FLAG/His-tagged HHAT (unknown origin) expressed in 293FT cells assessed as enzyme-mediated sonic hedgehog palmitoylation incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50249181(N-(4-chlorobenzyl)-2-((2R,6S,E)-5,12-dioxo-2-pheny...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of sonic hedgehog signaling in mouse Shh Light2 cells after 30 mins by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetZinc finger protein GLI1/GLI2(Mouse)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50249557(2-((3-(2-(dimethylamino)benzyl)-2-(pyridin-4-yl)-t...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of GLI1/GLI2 in mouse Shh Light2 cells assessed as reduction in endogenous hedgehog signalling in presence of Smo agonist SAG by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetZinc finger protein GLI2(Mouse)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50249102(4-(3,4,5-tri(pyridin-4-yl)thiophen-2-yl)pyridine |...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of GLI1/GLI2 in mouse Shh Light2 cells assessed as reduction in endogenous hedgehog signalling in presence of Smo agonist SAG by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed