Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50007002
TargetAmine oxidase [flavin-containing] B(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of MAO-B in rat brain using [14C]-phenylethylamine as substrate preincubated for 60 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50175503(Dimethyl-carbamic acid (R)-2-methyl-1-[2-(4-nitro-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat synaptosome SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50279266(5-(4-propargyl-piperazin-1-ylmethyl)-8-hydroxyquin...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse brain AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505282(CHEMBL4462662)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human histamine H3 receptor stably expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by Eu-cAMP tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50175503(Dimethyl-carbamic acid (R)-2-methyl-1-[2-(4-nitro-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of mouse brain AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50175500((S)-4-(1-(methylamino)-3-(4-nitrophenoxy)propyl)ph...)
Affinity DataIC50: 42nMAssay Description:Inhibition of rat synaptosome SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50175500((S)-4-(1-(methylamino)-3-(4-nitrophenoxy)propyl)ph...)
Affinity DataIC50: 101nMAssay Description:Inhibition of mouse brain AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM30130(Prozac | cid_62857 | Fluoxetin | CHEMBL41 | CHEMBL...)
Affinity DataIC50: 180nMAssay Description:Inhibition of rat synaptosome SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLipoxygenase(Soybean)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505285(CHEMBL4450603)
Affinity DataIC50: 340nMAssay Description:Inhibition of soya bean LOX assessed as reduction in formation of 13-hydroperoxylinoleic acid using sodium linoleate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)
Affinity DataIC50: 410nMAssay Description:Inhibition of MAO-A in rat brain using [14C]-5-hydroxytryptamine creatinine disulfate as substrate preincubated for 60 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM11682(2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethyl...)
Affinity DataIC50: 920nMAssay Description:Inhibition of AChE in human erythrocytes preincubated for 60 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM11682(2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rat synaptosome SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50279266(5-(4-propargyl-piperazin-1-ylmethyl)-8-hydroxyquin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rat synaptosome SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM30130(Prozac | cid_62857 | Fluoxetin | CHEMBL41 | CHEMBL...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mouse brain AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM11682(2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethyl...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of mouse brain AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505282(CHEMBL4462662)
Affinity DataIC50: 1.72E+4nMAssay Description:Inhibition of self-induced aggregation of amyloid beta (1 to 42) (unknown origin) incubated for 24 hrs by TEM analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 5.24E+4nMAssay Description:Inhibition of AChE in human erythrocytes preincubated for 60 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of MAO-A in rat brain using [14C]-5-hydroxytryptamine creatinine disulfate as substrate preincubated for 60 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLipoxygenase(Soybean)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505283(CHEMBL4513435)
Affinity DataIC50: 8.90E+4nMAssay Description:Inhibition of soya bean LOX assessed as reduction in formation of 13-hydroperoxylinoleic acid using sodium linoleate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of MAO-B in rat brain using [14C]-phenylethylamine as substrate preincubated for 60 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505284(CHEMBL4576324)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I][MePhe]NKB from human NK3 receptor expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505284(CHEMBL4576324)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505284(CHEMBL4576324)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50116743(3,5-Dichloro-N-{(R)-3-(3,4-dichloro-phenyl)-5-(4-{...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50116743(3,5-Dichloro-N-{(R)-3-(3,4-dichloro-phenyl)-5-(4-{...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50116743(3,5-Dichloro-N-{(R)-3-(3,4-dichloro-phenyl)-5-(4-{...)
Affinity DataKi:  945nMAssay Description:Displacement of [125I][MePhe]NKB from human NK3 receptor expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed