Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50010137
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50523450(CHEMBL4437012)
Affinity DataEC50:  81nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  2.70nMAssay Description:Agonist activity at D4R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gi-cAMP Glosensor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM160875(US9107923, 45 | US10093655, Example 45 | US1101490...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535455(CHEMBL4538358)
Affinity DataEC50:  450nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535447(CHEMBL4453318)
Affinity DataEC50:  35nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(1B) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50465935(CHEMBL4277264)
Affinity DataEC50:  11nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataEC50:  4.70nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at D2R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gi-cAMP Glosensor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535456(CHEMBL4475914)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535457(CHEMBL4449782)
Affinity DataEC50:  410nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535448(CHEMBL4469983)
Affinity DataEC50:  490nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataEC50:  1.80nMAssay Description:Agonist activity at D4R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gi-cAMP Glosensor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535447(CHEMBL4453318)
Affinity DataEC50:  4.40nMAssay Description:Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataEC50:  44nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(2) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at D2R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gi-cAMP Glosensor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535446(CHEMBL4565185)
Affinity DataEC50:  580nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataEC50:  360nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50523450(CHEMBL4437012)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50465935(CHEMBL4277264)
Affinity DataEC50:  320nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535454(CHEMBL4559240)
Affinity DataEC50:  950nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535453(CHEMBL4475239)
Affinity DataEC50:  360nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535452(CHEMBL4445861)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM160875(US9107923, 45 | US10093655, Example 45 | US1101490...)
Affinity DataEC50:  5.30nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535451(CHEMBL4470808)
Affinity DataEC50:  610nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535450(CHEMBL4458646)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535447(CHEMBL4453318)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535448(CHEMBL4469983)
Affinity DataEC50:  10nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535449(CHEMBL4573462)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535447(CHEMBL4453318)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based compe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based compe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535448(CHEMBL4469983)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based compe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM160875(US9107923, 45 | US10093655, Example 45 | US1101490...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based compe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)