Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50007839
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513202(CHEMBL4463050)
Affinity DataKi:  0.0450nMAssay Description:Inhibition of p53 protein binding to MDM2 in human SJSA1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513204(CHEMBL4537250)
Affinity DataKi:  0.440nMAssay Description:Inhibition of wild type p53 protein binding to MDM2 in human HCT116 cells by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513204(CHEMBL4537250)
Affinity DataKi:  0.440nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513202(CHEMBL4463050)
Affinity DataKi:  0.600nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513200(CHEMBL4514512)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513209(CHEMBL4440151)
Affinity DataKi:  0.880nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513203(CHEMBL4539285)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513205(CHEMBL4437666)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513211(CHEMBL4548050)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513206(CHEMBL4546186)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513206(CHEMBL4546186)
Affinity DataKi:  1.20nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513205(CHEMBL4437666)
Affinity DataKi:  1.20nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513200(CHEMBL4514512)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of MDMX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM31196(spiro-oxindole, 1)
Affinity DataKi:  8.5nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513202(CHEMBL4463050)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of p53 protein binding to MDM2 in human SJSA1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300119((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  13nMAssay Description:Inhibition of wild type p53 protein binding to MDM2 in human HCT116 cells by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300119((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  13nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50397778(CHEMBL2177813 | US9593129, Example 35)
Affinity DataIC50: 34nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50420273(CHEMBL2089208)
Affinity DataKi:  89nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50420268(CHEMBL2089203)
Affinity DataKi:  91nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM129722(US8815926, 1)
Affinity DataIC50: 170nMAssay Description:Inhibition of p53 derived Cy5-TFSDLWKLL peptide binding to human MDM2 (2 to 188 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50339398((+)-R-3-(4-Chlorophenyl)-3-(1-hydroxymethylcyclopr...)
Affinity DataKi:  170nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM31197(CHEMBL211045 | Nutlin-3 | med.21724, Compound 186)
Affinity DataKd:  240nMAssay Description:Binding affinity to MDM2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513207(CHEMBL4566706)
Affinity DataKi:  400nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513207(CHEMBL4566706)
Affinity DataIC50: 400nMAssay Description:Inhibition of MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein Mdm4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM129722(US8815926, 1)
Affinity DataIC50: 468nMAssay Description:Inhibition of p53 derived Cy5-TFSDLWKLL peptide binding to human MDMX (2 to 185 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50436049(CHEMBL2396744)
Affinity DataIC50: 490nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513201(CHEMBL4447592)
Affinity DataIC50: 600nMAssay Description:Inhibition of MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513201(CHEMBL4447592)
Affinity DataKi:  600nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM31314(1,4-benzodiazepine-2,5-dione, 12k)
Affinity DataIC50: 704nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM143333(US8969341, 1)
Affinity DataIC50: 4.16E+3nMAssay Description:Inhibition of p53 derived Cy5-TFSDLWKLL peptide binding to human MDMX (2 to 185 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513210(CHEMBL4548943)
Affinity DataKd:  6.36E+3nMAssay Description:Binding affinity to MDM2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM143333(US8969341, 1)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of p53 derived Cy5-TFSDLWKLL peptide binding to human MDM2 (2 to 188 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM31196(spiro-oxindole, 1)
Affinity DataKi:  8.50E+3nMAssay Description:Inhibition of wild type p53 protein binding to MDM2 in human HCT116 cells by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM129785(US8815926, 64)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of p53 derived Cy5-TFSDLWKLL peptide binding to human MDM2 (2 to 188 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513208(CHEMBL4539441)
Affinity DataKd:  9.68E+3nMAssay Description:Binding affinity to MDM2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM162123(US9051279, 106)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p53 derived Cy5-p53 peptide (18 to 26 residues) binding to human MDM2 (2 to 188 residues) after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein Mdm4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50014089(CHEMBL1236726)
Affinity DataEC50:  2.00E+4nMAssay Description:Inhibition of p53 protein binding to MDMX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM129785(US8815926, 64)
Affinity DataIC50: 2.78E+4nMAssay Description:Inhibition of p53 derived Cy5-TFSDLWKLL peptide binding to human MDMX (2 to 185 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50229787(CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)