Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50009025
Target5-hydroxytryptamine receptor 1A(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM21393(cid_1220 | CHEMBL56 | 7-(dipropylamino)-5,6,7,8-te...)
Affinity DataIC50: 0.280nMAssay Description:Displacement of [3H]OH-DPAT from human recombinant 5-HT1A receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...)
Affinity DataIC50: 0.820nMAssay Description:Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | Imipramin | IMIPRAMINE HYDROCHLORIDE | ...)
Affinity DataIC50: 4.10nMAssay Description:Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2B(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50024204(MESULERGINE | CHEMBL12314 | 4,7-dimethyl-(6aR,9S,1...)
Affinity DataIC50: 5.20nMAssay Description:Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524648(CHEMBL4579120)
Affinity DataIC50: 260nMAssay Description:Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524648(CHEMBL4579120)
Affinity DataIC50: 490nMAssay Description:Displacement of [3H]OH-DPAT from human recombinant 5-HT1A receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524649(CHEMBL4562303)
Affinity DataIC50: 680nMAssay Description:Displacement of [3H]OH-DPAT from human recombinant 5-HT1A receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524648(CHEMBL4579120)
Affinity DataIC50: 1.60E+3nMAssay Description:Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524648(CHEMBL4579120)
Affinity DataIC50: 1.80E+3nMAssay Description:Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524649(CHEMBL4562303)
Affinity DataIC50: 3.00E+3nMAssay Description:Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524648(CHEMBL4579120)
Affinity DataIC50: 7.40E+3nMAssay Description:Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524649(CHEMBL4562303)
Affinity DataIC50: 8.70E+3nMAssay Description:Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524649(CHEMBL4562303)
Affinity DataIC50: 1.50E+4nMAssay Description:Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524649(CHEMBL4562303)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524648(CHEMBL4579120)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [3H] mesulergine from human recombinant 5-HT2C receptor measured after 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM21393(cid_1220 | CHEMBL56 | 7-(dipropylamino)-5,6,7,8-te...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]OH-DPAT from human recombinant 5-HT1A receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | Imipramin | IMIPRAMINE HYDROCHLORIDE | ...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2B(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50024204(MESULERGINE | CHEMBL12314 | 4,7-dimethyl-(6aR,9S,1...)
Affinity DataKi:  2.80nMAssay Description:Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524648(CHEMBL4579120)
Affinity DataKi:  140nMAssay Description:Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524648(CHEMBL4579120)
Affinity DataKi:  310nMAssay Description:Displacement of [3H]OH-DPAT from human recombinant 5-HT1A receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524649(CHEMBL4562303)
Affinity DataKi:  420nMAssay Description:Displacement of [3H]OH-DPAT from human recombinant 5-HT1A receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524648(CHEMBL4579120)
Affinity DataKi:  870nMAssay Description:Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524648(CHEMBL4579120)
Affinity DataKi:  970nMAssay Description:Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524649(CHEMBL4562303)
Affinity DataKi:  1.60E+3nMAssay Description:Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524648(CHEMBL4579120)
Affinity DataKi:  3.40E+3nMAssay Description:Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524649(CHEMBL4562303)
Affinity DataKi:  4.70E+3nMAssay Description:Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524649(CHEMBL4562303)
Affinity DataKi:  8.20E+3nMAssay Description:Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524649(CHEMBL4562303)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50524648(CHEMBL4579120)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H] mesulergine from human recombinant 5-HT2C receptor measured after 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed