Compile Data Set for Download or QSAR
Report error Found 311 Enz. Inhib. hit(s) with all data for entry = 50008728
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00300nMAssay Description:Inhibition of NS5A N62S mutant in HCV genotype 2a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521721(CHEMBL4536960)
Affinity DataEC50:  0.00400nMAssay Description:Inhibition of NS5A in HCV genotype 3a S52 infected in human HuH7 transient chimeric replicon cells assessed as reduction in viral replication after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521747(CHEMBL4543321)
Affinity DataEC50:  0.00400nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 (L31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50505966(CHEBI:85089 | GS-5885 | Ledipasvir | Ledipasvir ac...)
Affinity DataEC50:  0.00400nMAssay Description:Inhibition of NS5A in wild type HCV genotype 1b infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521738(CHEMBL4437858)
Affinity DataEC50:  0.00400nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50505966(CHEBI:85089 | GS-5885 | Ledipasvir | Ledipasvir ac...)
Affinity DataEC50:  0.00400nMAssay Description:Inhibition of NS5A in HCV genotype 1b Con1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521721(CHEMBL4536960)
Affinity DataEC50:  0.00400nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 (L31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00400nMAssay Description:Inhibition of NS5A in HCV genotype 3a S52 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521726(CHEMBL4516340)
Affinity DataEC50:  0.00400nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521737(CHEMBL4457264)
Affinity DataEC50:  0.00400nMAssay Description:Inhibition of NS5A in HCV genotype 3a S52 infected in human HuH7 transient chimeric replicon cells assessed as reduction in viral replication after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00400nMAssay Description:Inhibition of NS5A in wild type HCV genotype 2b MD2b-1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521739(CHEMBL4550389)
Affinity DataEC50:  0.00500nMAssay Description:Inhibition of NS5A in HCV genotype 1b Con1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00500nMAssay Description:Inhibition of NS5A K44R mutant in HCV genotype 2a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521736(CHEMBL4574152)
Affinity DataEC50:  0.00500nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521738(CHEMBL4437858)
Affinity DataEC50:  0.00500nMAssay Description:Inhibition of NS5A in HCV genotype 1b Con1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521726(CHEMBL4516340)
Affinity DataEC50:  0.00500nMAssay Description:Inhibition of NS5A in HCV genotype 3a S52 infected in human HuH7 transient chimeric replicon cells assessed as reduction in viral replication after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521718(CHEMBL4587426)
Affinity DataEC50:  0.00600nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521716(CHEMBL4467926)
Affinity DataEC50:  0.00600nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521709(CHEMBL4468617)
Affinity DataEC50:  0.00600nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00600nMAssay Description:Inhibition of NS5A in HCV genotype 2b MD2b-1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521708(CHEMBL4557789)
Affinity DataEC50:  0.00600nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521709(CHEMBL4468617)
Affinity DataEC50:  0.00600nMAssay Description:Inhibition of NS5A in HCV genotype 3a S52 infected in human HuH7 transient chimeric replicon cells assessed as reduction in viral replication after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00600nMAssay Description:Inhibition of NS5A in HCV genotype 6a HK6 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521736(CHEMBL4574152)
Affinity DataEC50:  0.00600nMAssay Description:Inhibition of NS5A in HCV genotype 3a S52 infected in human HuH7 transient chimeric replicon cells assessed as reduction in viral replication after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00700nMAssay Description:Inhibition of NS5A in wild type HCV genotype 2b AY232738 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 day...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521719(CHEMBL4542363)
Affinity DataEC50:  0.00700nMAssay Description:Inhibition of NS5A L31M mutant in HCV genotype 2a JFH1 (M31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521716(CHEMBL4467926)
Affinity DataEC50:  0.00700nMAssay Description:Inhibition of NS5A in HCV genotype 4a ED43 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521731(CHEMBL4450375)
Affinity DataEC50:  0.00700nMAssay Description:Inhibition of NS5A L31M mutant in HCV genotype 2a JFH1 (M31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521717(CHEMBL4466184)
Affinity DataEC50:  0.00700nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 (L31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521713(CHEMBL4436929)
Affinity DataEC50:  0.00700nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 (L31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521733(CHEMBL4547877)
Affinity DataEC50:  0.00700nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521726(CHEMBL4516340)
Affinity DataEC50:  0.00800nMAssay Description:Inhibition of NS5A in HCV genotype 4a ED43 infected in human HuH7 transient chimeric replicon cells assessed as reduction in viral replication after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521737(CHEMBL4457264)
Affinity DataEC50:  0.00800nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521730(CHEMBL4449384)
Affinity DataEC50:  0.00800nMAssay Description:Inhibition of NS5A in HCV genotype 1a H77 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00800nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521738(CHEMBL4437858)
Affinity DataEC50:  0.00800nMAssay Description:Inhibition of NS5A in HCV genotype 1a H77 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521730(CHEMBL4449384)
Affinity DataEC50:  0.00800nMAssay Description:Inhibition of NS5A in HCV genotype 4a ED43 infected in human HuH7 transient chimeric replicon cells assessed as reduction in viral replication after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521721(CHEMBL4536960)
Affinity DataEC50:  0.00800nMAssay Description:Inhibition of NS5A in HCV genotype 4a ED43 infected in human HuH7 transient chimeric replicon cells assessed as reduction in viral replication after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.00800nMAssay Description:Inhibition of NS5A L31M mutant in HCV genotype 2a JFH1 (M31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521735(CHEMBL4576714)
Affinity DataEC50:  0.00900nMAssay Description:Inhibition of NS5A L31M mutant in HCV genotype 2a JFH1 (M31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521718(CHEMBL4587426)
Affinity DataEC50:  0.00900nMAssay Description:Inhibition of NS5A in HCV genotype 4a ED43 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00900nMAssay Description:Inhibition of NS5A in HCV genotype 4a ED43 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521743(CHEMBL4562949)
Affinity DataEC50:  0.00900nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 (L31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521733(CHEMBL4547877)
Affinity DataEC50:  0.00900nMAssay Description:Inhibition of NS5A in HCV genotype 4a ED43 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521716(CHEMBL4467926)
Affinity DataEC50:  0.00900nMAssay Description:Inhibition of NS5A in HCV genotype 2b MD2b-1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00900nMAssay Description:Inhibition of NS5A in HCV wild type genotype 2a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521729(CHEMBL4440405)
Affinity DataEC50:  0.0100nMAssay Description:Inhibition of NS5A L31M mutant in HCV genotype 2a JFH1 (M31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0100nMAssay Description:Inhibition of NS5A N62V mutant in HCV genotype 2a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521745(CHEMBL4575259)
Affinity DataEC50:  0.0100nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 (L31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0100nMAssay Description:Inhibition of NS5A P58S mutant in HCV genotype 2b infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
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