Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50008230
TargetSodium-dependent serotonin transporter(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50150105([2-(6-Fluoro-chroman-8-yloxy)-ethyl]-[3-(5-fluoro-...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of 5HT transporter (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50150093([2-(6-Fluoro-chroman-8-yloxy)-ethyl]-[2-(5-fluoro-...)
Affinity DataKi:  5nMAssay Description:Inhibition of 5HT transporter (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50150105([2-(6-Fluoro-chroman-8-yloxy)-ethyl]-[3-(5-fluoro-...)
Affinity DataKi:  30nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50150093([2-(6-Fluoro-chroman-8-yloxy)-ethyl]-[2-(5-fluoro-...)
Affinity DataKi:  30nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50516934(CHEMBL4468611)
Affinity DataIC50: 1.93E+3nMAssay Description:Inhibition of HIV1 3B Y181C mutant infected in human MT2 cells assessed as reduction in virus-induced cytopathogenicity after 3 days by BrightGlo luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50516933(CHEMBL4555803)
Affinity DataIC50: 6.22E+3nMAssay Description:Inhibition of recombinant human COX2 assessed as decrease in PGE2 release after 10 mins by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50516932(IDX899 | CHEMBL1652111)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of HIV1 reverse transcriptase Y181C/K103N double mutant infected in human MT4 cells assessed as reduction in virus-induced cytopathogenici...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50516935(CHEMBL4526073)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50516935(CHEMBL4526073)
Affinity DataIC50: 9.80E+5nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed