Compile Data Set for Download or QSAR
Report error Found 46 Enz. Inhib. hit(s) with all data for entry = 50008416
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  7.11E+3nMAssay Description:Binding affinity to human partial length PIK3CA I800L mutant (R108 to N1068 residues) expressed in mammalian expression system measured after 1 hr by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  7.11E+3nMAssay Description:Binding affinity to human partial length PIK3CA Q546K mutant (R108 to N1068 residues) expressed in mammalian expression system measured after 1 hr by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  5.32E+3nMAssay Description:Binding affinity to wild-type human full length ERK1 Q122L mutant (M1 to P379 residues) expressed in bacterial expression system measured after 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  5.32E+3nMAssay Description:Binding affinity to wild-type human full length ERK1 (M1 to P379 residues) expressed in bacterial expression system measured after 1 hr by kinomescan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  272nMAssay Description:Binding affinity to wild-type human partial length PLK2 (H58 to F354 residues) expressed in mammalian expression system measured after 1 hr by kinome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  78nMAssay Description:Binding affinity to wild-type human partial length AURKB (D25 to A303 residues) expressed in mammalian expression system measured after 1 hr by Kinom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  5.32E+3nMAssay Description:Binding affinity to wild-type human full length ERK2 (M1 to S360 residues) expressed in bacterial expression system measured after 1 hr by kinomescan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  289nMAssay Description:Binding affinity to wild-type human full length AURKC (M1 to S275 residues) expressed in bacterial expression system measured after 1 hr by Kinomesca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human full length CDK4/cyclinD1 F93L mutant (M1 to E303 residues) expressed in mammalian expression system measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human full length CDK5 (M1 to P292 residues) expressed in bacterial expression system measured after 1 hr by kinomescan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 10(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human full-length CDK10 (M1 to P360 residues) expressed in mammalian expression system measured after 1 hr by kinomesca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 6(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  5.32E+3nMAssay Description:Binding affinity to wild-type human partial length ERK3 (M1 to P413 residues) expressed in bacterial expression system measured after 1 hr by kinomes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  7.11E+3nMAssay Description:Binding affinity to human partial length PIK3CA E545A mutant (R108 to N1068 residues) expressed in mammalian expression system measured after 1 hr by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 15(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  5.32E+3nMAssay Description:Binding affinity to wild-type human partial length ERK8 (M1 to P437 residues) expressed in bacterial expression system measured after 1 hr by kinomes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human full length CDK4/cyclinD3 (M1 to E303 residues) expressed in mammalian expression system measured after 1 hr by k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  5.32E+3nMAssay Description:Binding affinity to wild-type human partial length ERK5 (M1 to A409 residues) expressed in bacterial expression system measured after 1 hr by kinomes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  55nMAssay Description:Binding affinity to wild-type human partial length PLK1 (A33 to F325 residues) expressed in mammalian expression system measured after 1 hr by kinome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human full-length CDK1 (M1 to M297 residues) expressed in mammalian expression system measured after 1 hr by kinomescan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  7.11E+3nMAssay Description:Binding affinity to wild-type human partial length PIK3C2B (M1 to L1634 residues) expressed in mammalian expression system measured after 1 hr by kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  23nMAssay Description:Binding affinity to wild-type human partial length AURKA (E122 to K401 residues) expressed in mammalian expression system measured after 1 hr by Kino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human partial length CDK12 (P697 to E1077 residues) expressed in mammalian expression system measured after 1 hr by kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  7.11E+3nMAssay Description:Binding affinity to human partial length PIK3CA H1047L mutant (R108 to N1068 residues) expressed in mammalian expression system measured after 1 hr b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 20(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human full-length CDK20 (M1 to G346 residues) expressed in mammalian expression system measured after 1 hr by kinomesca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  7.11E+3nMAssay Description:Binding affinity to wild-type human partial length PIK3C2G (M1 to I1446 residues) expressed in mammalian expression system measured after 1 hr by kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  456nMAssay Description:Binding affinity to wild-type human partial length PLK3 (A42 to L334 residues) expressed in mammalian expression system measured after 1 hr by kinome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human full length CDK9 (M1 to F372 residues) expressed in bacterial expression system measured after 1 hr by kinomescan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human full length CDK4/cyclinD1 (M1 to E303 residues) expressed in mammalian expression system measured after 1 hr by k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  7.11E+3nMAssay Description:Binding affinity to wild-type human partial length PIK3CD (R108 to Q1044 residues) expressed in mammalian expression system measured after 1 hr by ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  7.11E+3nMAssay Description:Binding affinity to wild-type human partial length PIK3CG (S144 to A1102 residues) expressed in mammalian expression system measured after 1 hr by ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human full length CDK2 (M1 to L298 residues) expressed in bacterial expression system measured after 1 hr by kinomescan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human full length CDK7 (M1 to L344 residues) expressed in mammalian expression system measured after 1 hr by kinomescan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human partial length CDK8 (M1 to T360 residues) expressed in bacterial expression system measured after 1 hr by kinomes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 19(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human partial length CDK11 (M1 to N360 residues) expressed in mammalian expression system measured after 1 hr by kinome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 4(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  5.32E+3nMAssay Description:Binding affinity to wild-type human partial length ERK4 (M1 to L365 residues) expressed in bacterial expression system measured after 1 hr by kinomes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human full-length CDK6 (M1 to A326 residues) expressed in mammalian expression system measured after 1 hr by kinomescan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human full length CDK3 (M1 to H305 residues) expressed in bacterial expression system measured after 1 hr by kinomescan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human full length CDK4 (M1 to E303 residues) expressed in mammalian expression system measured after 1 hr by kinomescan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  7.11E+3nMAssay Description:Binding affinity to wild-type human partial length PIK3CB (P118 to S1070 residues) expressed in mammalian expression system measured after 1 hr by ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  7.11E+3nMAssay Description:Binding affinity to human partial length PIK3CA M1043I mutant (R108 to N1068 residues) expressed in mammalian expression system measured after 1 hr b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  7.11E+3nMAssay Description:Binding affinity to human partial length PIK3CA H1047Y mutant (R108 to N1068 residues) expressed in mammalian expression system measured after 1 hr b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  7.11E+3nMAssay Description:Binding affinity to human partial length PIK3CA E545K mutant (R108 to N1068 residues) expressed in mammalian expression system measured after 1 hr by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  7.11E+3nMAssay Description:Binding affinity to human partial length PIK3CA E542K mutant (R108 to N1068 residues) expressed in mammalian expression system measured after 1 hr by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  7.11E+3nMAssay Description:Binding affinity to human partial length PIK3CA C420R mutant (R108 to N1068 residues) expressed in mammalian expression system measured after 1 hr by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  7.11E+3nMAssay Description:Binding affinity to wild-type human partial length PIK3CA (R108 to N1068 residues) expressed in mammalian expression system measured after 1 hr by ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50240826(AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...)
Affinity DataIC50: 350nMAssay Description:Inhibition of PLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PLK1(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50: 830nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PLK1 (1 to 603 residues) expressed in baculovirus expression system using casein as substrate m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed