Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50007909
TargetPoly [ADP-ribose] polymerase 1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513904(CHEMBL4546114)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human PARP1 expressed in Escherichia coli incubated for 15 to 40 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513902(CHEMBL4442022)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human PARP1 expressed in Escherichia coli incubated for 15 to 40 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513901(CHEMBL4579526)
Affinity DataIC50: 2nMAssay Description:Inhibition of human PARP1 expressed in Escherichia coli using histone as substrate by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50006469(CHEMBL69956 | [8-Oxo-7-(5-trifluoromethyl-benzothi...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human placenta Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50268124(CHEMBL4078014)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50009781(CHEMBL20169 | [3-(5-Bromo-benzothiazol-2-ylmethyl)...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human placenta Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50006481(CHEMBL73560 | [1-(5,7-Difluoro-benzothiazol-2-ylme...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50008471(CHEMBL143234 | [3-(5,7-Difluoro-benzooxazol-2-ylme...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human placenta Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of PARP1 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50006471(CHEMBL68580 | [4-Oxo-3-(5-trifluoromethyl-benzothi...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50268134(CHEMBL4097093)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of PARP1 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of human PARP1 expressed in Escherichia coli incubated for 10 mins by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513903(CHEMBL4547590)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of human PARP1 expressed in Escherichia coli incubated for 10 mins by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50006463(CHEMBL21091 | (3-Benzothiazol-2-ylmethyl-4-oxo-3,4...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human placenta Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513914(CHEMBL4436968)
Affinity DataIC50: 20nMAssay Description:Inhibition of human Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513913(CHEMBL4458061)
Affinity DataIC50: 46nMAssay Description:Inhibition of human Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50028859(CHEMBL3342698)
Affinity DataIC50: 50nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in IL-beta induced PGE2 release preincubated for 30 mins followed by IL-beta addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513909(CHEMBL4541764)
Affinity DataKi:  61nMAssay Description:Inhibition of Acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate by Ellman's spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513907(CHEMBL4579543)
Affinity DataKi:  61nMAssay Description:Inhibition of Acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate by Ellman's spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513908(CHEMBL4453373)
Affinity DataKi:  61nMAssay Description:Inhibition of Acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate by Ellman's spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513900(CHEMBL4444582)
Affinity DataKi:  61nMAssay Description:Inhibition of Acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate by Ellman's spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513912(CHEMBL4524569)
Affinity DataKi:  61nMAssay Description:Inhibition of Acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate by Ellman's spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513910(CHEMBL4450818)
Affinity DataIC50: 97nMAssay Description:Inhibition of N-terminal GST-tagged human PARP1 expressed in a Baculovirus infected Sf9 insect cells using biotinylated substrate incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 100nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 100nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 139nMAssay Description:Inhibition of N-terminal GST-tagged human PARP1 expressed in a Baculovirus infected Sf9 insect cells using biotinylated substrate incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513905(CHEMBL4475847)
Affinity DataIC50: 420nMAssay Description:Inhibition of C-terminal His4-tagged Aurora A (unknown origin) using PKB-GSK2 biotinylated peptide as substrate incubated for 90 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 426nMAssay Description:Inhibition of Acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate by Ellman's spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513911(CHEMBL4580842)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human PARP1 expressed in Escherichia coli incubated for 15 to 40 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 1(Sheep)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513906(CHEMBL4549769)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of ovine COX1 preincubated for 5 mins followed by arachidonic acid addition and measured after 2 mins by colorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 1(Sheep)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of ovine COX1 preincubated for 5 mins followed by arachidonic acid addition and measured after 2 mins by colorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM160509(US9682969, 1 | US10280160, Example 1.)
Affinity DataEC50: <1.00E+4nMAssay Description:Inhibition of human CFTR F508 deletion mutant expressed in rat FRT cells coexpressing YFP-H148Q/I152L 25,22 incubated for 60 to 120 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed