Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50009138
TargetSodium/bile acid cotransporter(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50386790(CHEMBL1829174 | CHEMBL2047159 | TAK-875 | US119052...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of NTCP in human hepatocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50030474(US9562012, rosiglitazone | CHEBI:50122 | Avandamet...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of HA-tagged human NTCP expressed in human U2OS cells assessed as reduction in [14C]taurocholate uptake preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50009073(cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carba...)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of HA-tagged human NTCP expressed in human U2OS cells assessed as reduction in [14C]taurocholate uptake preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM18862(2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]ac...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of HA-tagged human NTCP expressed in human U2OS cells assessed as reduction in [14C]taurocholate uptake preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50103596(CHEBI:9334 | Azulfidine | Azulfidine EN | Azulfidi...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of HA-tagged human NTCP expressed in human U2OS cells assessed as reduction in [14C]taurocholate uptake preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50042235(2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of NTCP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM86704(CAS_93957-54-1 | Fluvastatin | cid_446155)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant NTCP expressed in CHO cells assessed as reduction in [3H]taurocholate uptake incubated for 2 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50395626(ACT-064992 | MACITENTAN)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human recombinant NTCP expressed in CHO cells assessed as reduction in [3H]taurocholate uptake preincubated for 1 hr by radioactive sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50061101(4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyph...)
Affinity DataIC50: 3.00E+7nMAssay Description:Inhibition of NTCP in human hepatocytes assessed as reduction in Na+-dependent [3H]taurocholate uptake measured at 45s following compound addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed