Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50009619
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human RXRalpha LBD expressed in African green monkey COS1 cells incubated for 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human RXRalpha LBD expressed in African green monkey COS1 cells incubated for 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530499(CHEMBL4449685)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human RXRalpha LBD expressed in African green monkey COS1 cells incubated for 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530499(CHEMBL4449685)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human RXRalpha LBD expressed in African green monkey COS1 cells incubated for 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Affinity DataKi:  150nMAssay Description:Displacement of 9-cis-[11,12-3H]-retinoic acid from human RXRalpha LBD incubated for overnight by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Affinity DataKi:  150nMAssay Description:Displacement of 9-cis-[11,12-3H]-retinoic acid from human RXRalpha LBD incubated for overnight by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50339081(6-[Ethyl-(3-isobutoxy-4-isopropylphenyl)amino]nico...)
Affinity DataKi:  182nMAssay Description:Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50339081(6-[Ethyl-(3-isobutoxy-4-isopropylphenyl)amino]nico...)
Affinity DataKi:  182nMAssay Description:Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530499(CHEMBL4449685)
Affinity DataKi:  230nMAssay Description:Displacement of 9-cis-[11,12-3H]-retinoic acid from human RXRalpha LBD incubated for overnight by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530499(CHEMBL4449685)
Affinity DataKi:  230nMAssay Description:Displacement of 9-cis-[11,12-3H]-retinoic acid from human RXRalpha LBD incubated for overnight by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530499(CHEMBL4449685)
Affinity DataKd:  233nMAssay Description:Binding affinity to human RXRalpha LBD incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530499(CHEMBL4449685)
Affinity DataKd:  233nMAssay Description:Binding affinity to human RXRalpha LBD incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Affinity DataKi:  379nMAssay Description:Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Affinity DataKi:  379nMAssay Description:Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM31892(CHEMBL705 | 9-cis retinoic acid | alitretinoin | P...)
Affinity DataKi:  583nMAssay Description:Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM31892(CHEMBL705 | 9-cis retinoic acid | alitretinoin | P...)
Affinity DataKi:  583nMAssay Description:Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50210259(all-cis-docosa-4,7,10,13,16,19-hexaenoic acid | Do...)
Affinity DataKi:  6.29E+3nMAssay Description:Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50210259(all-cis-docosa-4,7,10,13,16,19-hexaenoic acid | Do...)
Affinity DataKi:  6.29E+3nMAssay Description:Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242349(5,8,11,14,17-EICOSAPENTAENOIC ACID | 5Z,8Z,11Z,14Z...)
Affinity DataKi:  7.63E+3nMAssay Description:Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242349(5,8,11,14,17-EICOSAPENTAENOIC ACID | 5Z,8Z,11Z,14Z...)
Affinity DataKi:  7.63E+3nMAssay Description:Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed