Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50007615
TargetHistone deacetylase(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50220817(CHEMBL57792)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of HDAC in human K562 cell extracts using (QSY-7)-RGGRGLGK(Ac)-GGARRHRK(TAMRA)NH2 as substrate preincubated for 30 mins followed by additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50510962(CHEMBL4454646)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human C-terminal GST/His-tagged HDAC3 (1 to 428 residues) co-expressed with human N-terminal GST-tagged NCOR2 (395 to 489 r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM25150(Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC in human HeLa cell extractsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 20nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50: 36nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50: 47nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50242817(CHEMBL4087968 | US20240150300, Compound Chidamide)
Affinity DataIC50: 67nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50242817(CHEMBL4087968 | US20240150300, Compound Chidamide)
Affinity DataIC50: 78nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458323(CHEMBL4207448)
Affinity DataIC50: 78nMAssay Description:Inhibition of HDAC1 (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50242817(CHEMBL4087968 | US20240150300, Compound Chidamide)
Affinity DataIC50: 95nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 143nMAssay Description:Inhibition of HDAC in human K562 cell extracts using (QSY-7)-RGGRGLGK(Ac)-GGARRHRK(TAMRA)NH2 as substrate preincubated for 30 mins followed by additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 2(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50242817(CHEMBL4087968 | US20240150300, Compound Chidamide)
Affinity DataIC50: 160nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50510963(D-24851 | Indibulin | ZIO-301)
Affinity DataIC50: 250nMAssay Description:Inhibition of bovine brain tubulin polymerization incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458323(CHEMBL4207448)
Affinity DataIC50: 290nMAssay Description:Inhibition of HDAC6 (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458323(CHEMBL4207448)
Affinity DataIC50: 380nMAssay Description:Inhibition of HDAC8 (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50510964(CHEMBL4465340)
Affinity DataIC50: 2.12E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization by spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAromatase(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50510965(CHEMBL4564431)
Affinity DataIC50: 8.72E+3nMAssay Description:Inhibition of recombinant human CYP19 using MFC as substrate incubated for 30 mins in presence of NADPH by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50244142(CHEMBL4086356 | US10533010, Example I-240 | US1120...)
Affinity DataKi: <1nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50148863(CHEMBL3769721 | US10533010, Example I-177 | US1120...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50510966(CHEMBL4457559)
Affinity DataKi:  2.40nMAssay Description:Inhibition of MCL1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50244142(CHEMBL4086356 | US10533010, Example I-240 | US1120...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs in presence of 1% FBS by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50038704(CHEMBL3354882)
Affinity DataKi:  5.30nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50244111(CHEMBL4082389 | US10533010, Example I-39 | US11208...)
Affinity DataKi:  23nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50244111(CHEMBL4082389 | US10533010, Example I-39 | US11208...)
Affinity DataKi:  108nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs in presence of 1% FBS by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50424732(CHEMBL2314209)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs in presence of 1% FBS by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)