Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50008474
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519613(CHEMBL4557431)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of Mcl1 (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519622(CHEMBL2442251)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human BCl2 expressed in Escherichia coli BL21 (DE3) pLysS cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519613(CHEMBL4557431)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of Bcl-xL (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519619(CHEMBL4444429)
Affinity DataIC50: 10nMAssay Description:Inhibition of TAMRA-labeled BIM BH3 peptide binding to human Mcl1 (171 to 327 residues) incubated for 120 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataIC50: 14nMAssay Description:Inhibition of Bcl-xL (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519620(CHEMBL4519659)
Affinity DataIC50: 20nMAssay Description:Displacement of fluorescein labelled Puma-BH3 peptide from human BCl2 expressed in Escherichia coli BL21 (DE3) pLysS cells incubated for 2 hrs by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519616(CHEMBL4449176)
Affinity DataIC50: 40nMAssay Description:Inhibition of TAMRA-labeled BIM BH3 peptide binding to human Mcl1 (171 to 327 residues) incubated for 120 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50508939(CHEMBL4443085)
Affinity DataIC50: 42nMAssay Description:Inhibition of N-terminal GST-tagged-Mcl1 (E171 to G327) (unknown origin) expressed in Escherichia coli using HyLite Fluor 647-labeled Bim peptide C a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519623(CHEMBL4521431)
Affinity DataIC50: 100nMAssay Description:Displacement of fluorescein labelled Puma-BH3 peptide from His-tagged-TEV fused human Mcl-1 incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519610(CHEMBL4533049)
Affinity DataIC50: 300nMAssay Description:Inhibition of TAMRA-labeled BIM BH3 peptide binding to human Mcl1 (171 to 327 residues) incubated for 120 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetApoptosis regulator Bcl-2(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519621(CHEMBL4453237)
Affinity DataIC50: 500nMAssay Description:Displacement of fluorescein labelled Puma-BH3 peptide from human BCl2 expressed in Escherichia coli BL21 (DE3) pLysS cells incubated for 2 hrs by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50078151(CHEMBL3417691)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of N-terminal GST-tagged-Mcl1 (E171 to G327) (unknown origin) expressed in Escherichia coli using HyLite Fluor 647-labeled Bim peptide C a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519625(CHEMBL4438456)
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of fluorescein labelled Puma-BH3 peptide from human BCl2 expressed in Escherichia coli BL21 (DE3) pLysS cells incubated for 2 hrs by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50449369(CHEMBL3126333)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Mcl1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50449368(CHEMBL3126334)
Affinity DataIC50: 1.60E+5nMAssay Description:Inhibition of Mcl1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519615(CHEMBL4529605)
Affinity DataIC50: 5.20E+5nMAssay Description:Displacement of fluorescein labelled Puma-BH3 peptide from His-tagged-TEV fused human Mcl-1 incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi:  0.0180nMAssay Description:Inhibition of wild-type BCL-2 (unknown origin) expressed in Escherichia coli BL21 cells using biotinylated BIMBH3 or BAXBH3 peptide by surface plasmo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519624(CHEMBL4468645)
Affinity DataKi:  0.0400nMAssay Description:Inhibition of TAMRA-labeled BIM BH3 peptide binding to human Mcl1 (171 to 327 residues) incubated for 120 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetApoptosis regulator Bcl-2(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519612(CHEMBL591907)
Affinity DataKi:  0.0440nMAssay Description:Inhibition of His-tagged Bcl-2 (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519617(CHEMBL4560418)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of TAMRA-labeled BIM BH3 peptide binding to human Mcl1 (171 to 327 residues) incubated for 120 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetApoptosis regulator Bcl-2(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM178570(US9125913, 129)
Affinity DataKi: <0.100nMAssay Description:Inhibition of His-tagged Bcl-2 (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519618(CHEMBL4465718)
Affinity DataKi:  0.140nMAssay Description:Inhibition of TAMRA-labeled BIM BH3 peptide binding to human Mcl1 (171 to 327 residues) incubated for 120 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM333146(US10196404, Example 1 | Compound I | US10196404, E...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of N-terminal GST-tagged-Mcl1 (E171 to G327) (unknown origin) expressed in Escherichia coli using HyLite Fluor 647-labeled Bim peptide C a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519609(CHEMBL4561305)
Affinity DataKi:  0.360nMAssay Description:Inhibition of wild-type BCL-2 (unknown origin) expressed in Escherichia coli BL21 cells using biotinylated BIMBH3 or BAXBH3 peptide by surface plasmo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50244142(CHEMBL4086356 | US10533010, Example I-240 | US1120...)
Affinity DataKi: <1nMAssay Description:Inhibition of FITC-labelled BAK peptide binding to human MBP-fused Mcl-1 (172 to 327 residues) expressed in Escherichia coli BL21 CodonPlus (DE3) RIL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519614(CHEMBL4439276)
Affinity DataKi: <1.20nMAssay Description:Displacement of fluorescein labelled Puma-BH3 peptide from C-terminal MBP-fused human Mcl-1 (173 to 321 residues) expressed in Escherichia coli BL21(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50244111(CHEMBL4082389 | US10533010, Example I-39 | US11208...)
Affinity DataKi:  23nMAssay Description:Inhibition of FITC-labelled BAK peptide binding to human MBP-fused Mcl-1 (172 to 327 residues) expressed in Escherichia coli BL21 CodonPlus (DE3) RIL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50424732(CHEMBL2314209)
Affinity DataKi:  55nMAssay Description:Inhibition of Mcl1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetApoptosis regulator Bcl-2(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519611(CHEMBL4534249)
Affinity DataKi:  59nMAssay Description:Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed