Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50011289
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataKi:  2.20nMAssay Description:Displacement of alexa fluor 647-labeled kinase tracer 314 from recombinant N-terminal His6-tagged p110alpha (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
LigandPNGBDBM50546184(CHEMBL4758284)
Affinity DataKi:  2.70nMAssay Description:Displacement of alexa fluor 647-labeled kinase tracer 314 from recombinant N-terminal His6-tagged p110alpha (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
LigandPNGBDBM50546185(CHEMBL4749136)
Affinity DataKi:  3.40nMAssay Description:Displacement of alexa fluor 647-labeled kinase tracer 314 from recombinant N-terminal His6-tagged p110alpha (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
LigandPNGBDBM50546186(CHEMBL4754767)
Affinity DataKi:  4.40nMAssay Description:Displacement of alexa fluor 647-labeled kinase tracer 314 from recombinant N-terminal His6-tagged p110alpha (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546185(CHEMBL4749136)
Affinity DataKi:  14nMAssay Description:Displacement of alexa fluor 647-labeled kinase tracer 314 from recombinant human N-terminal GST-fused mTOR (1360 to 2549 residues) expressed in bacul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataIC50: 17nMAssay Description:Inhibition of mTORC2 in human A2058 cells assessed as reduction in PKB phosphorylation at S473 residue incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546184(CHEMBL4758284)
Affinity DataKi:  21nMAssay Description:Displacement of alexa fluor 647-labeled kinase tracer 314 from recombinant human N-terminal GST-fused mTOR (1360 to 2549 residues) expressed in bacul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546186(CHEMBL4754767)
Affinity DataKi:  29nMAssay Description:Displacement of alexa fluor 647-labeled kinase tracer 314 from recombinant human N-terminal GST-fused mTOR (1360 to 2549 residues) expressed in bacul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataKi:  33nMAssay Description:Displacement of alexa fluor 647-labeled kinase tracer 314 from recombinant human N-terminal GST-fused mTOR (1360 to 2549 residues) expressed in bacul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataIC50: 61nMAssay Description:Inhibition of mTORC1 in human A2058 cells assessed as reduction in ribosomal protein S6 phosphorylation at Ser235/236 residues incubated for 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546184(CHEMBL4758284)
Affinity DataIC50: 64nMAssay Description:Inhibition of mTORC2 in human A2058 cells assessed as reduction in PKB phosphorylation at S473 residue incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546185(CHEMBL4749136)
Affinity DataIC50: 73nMAssay Description:Inhibition of mTORC2 in human A2058 cells assessed as reduction in PKB phosphorylation at S473 residue incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546186(CHEMBL4754767)
Affinity DataIC50: 84nMAssay Description:Inhibition of mTORC2 in human A2058 cells assessed as reduction in PKB phosphorylation at S473 residue incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546185(CHEMBL4749136)
Affinity DataIC50: 91nMAssay Description:Inhibition of mTORC1 in human A2058 cells assessed as reduction in ribosomal protein S6 phosphorylation at Ser235/236 residues incubated for 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546184(CHEMBL4758284)
Affinity DataIC50: 116nMAssay Description:Inhibition of mTORC1 in human A2058 cells assessed as reduction in ribosomal protein S6 phosphorylation at Ser235/236 residues incubated for 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546186(CHEMBL4754767)
Affinity DataIC50: 139nMAssay Description:Inhibition of mTORC1 in human A2058 cells assessed as reduction in ribosomal protein S6 phosphorylation at Ser235/236 residues incubated for 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C19 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed