Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50010334
TargetAldo-keto reductase family 1 member B10(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 35nMAssay Description:Inhibition of AKR1B10 (unknown origin) pretreated with 0.25M DMSO followed by compound treatment by DMSO-perturbation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.3M DMSO followed by compound addition by DMSO-pertu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 39nMAssay Description:Inhibition of AKR1B10 (unknown origin) pretreated with 0.42M DMSO followed by compound treatment by DMSO-perturbation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.7M DMSO followed by compound addition by DMSO-pertu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 53nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 1M DMSO followed by compound addition by DMSO-perturb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.3M DMSO followed by compound addition by DMSO-pertu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.7M DMSO followed by compound addition by DMSO-pertu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 971nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.3M DMSO followed by compound addition by DMSO-pertu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.7M DMSO followed by compound addition by DMSO-pertu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50088507(CHEMBL1908021 | CHEBI:63804)
Affinity DataIC50: 4.06E+4nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50088507(CHEMBL1908021 | CHEBI:63804)
Affinity DataIC50: 4.06E+4nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.3M DMSO followed by compound addition by DMSO-pertu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50088507(CHEMBL1908021 | CHEBI:63804)
Affinity DataIC50: 4.79E+4nMAssay Description:Aggregation-based inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50088507(CHEMBL1908021 | CHEBI:63804)
Affinity DataIC50: 6.42E+4nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.7M DMSO followed by compound addition by DMSO-pertu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50537705(CHEMBL4640749)
Affinity DataIC50: 6.56E+4nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.3M DMSO followed by compound addition by DMSO-pertu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50537705(CHEMBL4640749)
Affinity DataIC50: 6.56E+4nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50537705(CHEMBL4640749)
Affinity DataIC50: 7.19E+4nMAssay Description:Aggregation-based inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50022454(spiro[tetrahydro-1H-imidazole-4,1'-(1',2',3',4'-te...)
Affinity DataIC50: 8.01E+4nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50022454(spiro[tetrahydro-1H-imidazole-4,1'-(1',2',3',4'-te...)
Affinity DataIC50: 1.14E+5nMAssay Description:Aggregation-based inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50: 1.26E+5nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50537704(CHEMBL1869748)
Affinity DataIC50: 1.60E+5nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50537705(CHEMBL4640749)
Affinity DataIC50: 1.78E+5nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.7M DMSO followed by compound addition by DMSO-pertu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50537706(CHEMBL4635409)
Affinity DataIC50: 2.91E+5nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50537707(CHEMBL4648564)
Affinity DataIC50: 2.95E+5nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50537704(CHEMBL1869748)
Affinity DataIC50: 3.19E+5nMAssay Description:Aggregation-based inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50537707(CHEMBL4648564)
Affinity DataIC50: 4.33E+5nMAssay Description:Aggregation-based inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50537706(CHEMBL4635409)
Affinity DataIC50: 4.53E+5nMAssay Description:Aggregation-based inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed