Compile Data Set for Download or QSAR
Report error Found 69 Enz. Inhib. hit(s) with all data for entry = 50007641
TargetSodium/glucose cotransporter 2(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50381537(CHEMBL2017954)
Affinity DataEC50:  5nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetKetohexokinase(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241205(CHEMBL1463512)
Affinity DataKd:  4.40E+4nMAssay Description:Binding affinity to recombinant His-tagged human KHK expressed in Escherichia coli in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511114(CHEMBL4438585)
Affinity DataEC50:  59nMAssay Description:Displacement of [125I]GLP-1 from human GLP-1R (7 to 36 residues) expressed in HEK293 or CHO cell membranes after 120 mins by radioligand binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511115(CHEMBL4552590)
Affinity DataEC50:  330nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataEC50:  1.10nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 1(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386885(CANAGLIFLOZIN HYDRATE | CANAGLIFLOZIN | US10752604...)
Affinity DataEC50:  910nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386885(CANAGLIFLOZIN HYDRATE | CANAGLIFLOZIN | US10752604...)
Affinity DataEC50:  2.20nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM150162(US8980829, EMPAGLIFLOZIN | empagliflozin | BI-1077...)
Affinity DataEC50:  3nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50381554(CHEMBL2018096)
Affinity DataEC50:  7.40nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50315426((1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4...)
Affinity DataEC50:  4.00E+3nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50213714((R)-2-(4-(2-ethoxy-3-(4-(trifluoromethyl)phenoxy)p...)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 1(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM150162(US8980829, EMPAGLIFLOZIN | empagliflozin | BI-1077...)
Affinity DataEC50:  8.30E+3nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511115(CHEMBL4552590)
Affinity DataEC50:  36nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM237920(US9394285, 1)
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of rat hepatocytes AMPK alpha1/beta2/gamma1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50511116(CHEMBL4167177)
Affinity DataEC50:  7.5nMAssay Description:Activation of rat hepatocytes AMPK alpha1/beta2/gamma1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21675(6alpha-Ethyl-Chenodeoxycholic Acid | (4R)-4-[(1S,2...)
Affinity DataEC50:  85nMAssay Description:Agonist activity at FXR (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataEC50:  90nMAssay Description:Agonist activity at FXR (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataEC50:  970nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185707(CHEMBL3822773)
Affinity DataEC50:  209nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50213714((R)-2-(4-(2-ethoxy-3-(4-(trifluoromethyl)phenoxy)p...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at PPARdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 1(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataEC50: >8.00E+3nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21674(Chenodeoxycholic Acid | CDCA | (4R)-4-[(1S,2S,5R,7...)
Affinity DataEC50:  8.66E+3nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511109(Cilofexor | GS 9674 | Gs-9674 | PX-104 | PX104 | U...)
Affinity DataEC50:  41nMAssay Description:Agonist activity at FXR (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50213714((R)-2-(4-(2-ethoxy-3-(4-(trifluoromethyl)phenoxy)p...)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataEC50:  9.20nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085042(Finofibrate | Tricor (TN) | CHEMBL672 | propan-2-y...)
Affinity DataEC50:  3.00E+5nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50381554(CHEMBL2018096)
Affinity DataEC50:  1.90E+3nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  3.00E+5nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor alpha(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataEC50:  6.70E+3nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  3.00E+4nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50315426((1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4...)
Affinity DataEC50:  2.30nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50502541(Elafibranor | GFT-505 | Gft505)
Affinity DataEC50:  10nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor delta(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50502541(Elafibranor | GFT-505 | Gft505)
Affinity DataEC50:  10nMAssay Description:Agonist activity at PPARdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21675(6alpha-Ethyl-Chenodeoxycholic Acid | (4R)-4-[(1S,2...)
Affinity DataEC50:  99nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50090940(3-(2-{4-[3-(2,6-Dichloro-phenyl)-5-methyl-isoxazol...)
Affinity DataEC50:  70nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185707(CHEMBL3822773)
Affinity DataEC50:  4nMAssay Description:Agonist activity at FXR (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511109(Cilofexor | GS 9674 | Gs-9674 | PX-104 | PX104 | U...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511119(CHEMBL4518127)
Affinity DataEC50:  1.20nMAssay Description:Displacement of [125I]GLP-1 from human GLP-1R (7 to 36 residues) expressed in HEK293 or CHO cell membranes after 120 mins by radioligand binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50090940(3-(2-{4-[3-(2,6-Dichloro-phenyl)-5-methyl-isoxazol...)
Affinity DataEC50:  4.10E+3nMAssay Description:Agonist activity at FXR (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085042(Finofibrate | Tricor (TN) | CHEMBL672 | propan-2-y...)
Affinity DataEC50:  3.00E+4nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)
Affinity DataEC50:  12nMAssay Description:Displacement of [125I]GLP-1 from human GLP-1R (7 to 36 residues) expressed in HEK293 or CHO cell membranes after 120 mins by radioligand binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  40nMAssay Description:Activation of rat hepatocytes AMPK alpha1/beta2/gamma1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetKetohexokinase(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241206(CHEMBL1500542)
Affinity DataKd:  6.20E+4nMAssay Description:Binding affinity to recombinant His-tagged human KHK expressed in Escherichia coli in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetC-C chemokine receptor type 7(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of CCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | US11186587, Example ND-630 | US109...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of ACC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 2(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | US11186587, Example ND-630 | US109...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of ACC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 2(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511117(CHEMBL4557289)
Affinity DataIC50: 3nMAssay Description:Inhibition of ACC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511117(CHEMBL4557289)
Affinity DataIC50: 3nMAssay Description:Inhibition of ACC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
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