Compile Data Set for Download or QSAR
Report error Found 81 Enz. Inhib. hit(s) with all data for entry = 50011097
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544867(CHEMBL4642696)
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544866(CHEMBL4643904 | US11292781, Compound T146)
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544868(CHEMBL4644765)
Affinity DataIC50: 17nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544865(CHEMBL4638971 | US11292781, Compound T145)
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544864(CHEMBL4646395 | US11292781, Compound T169)
Affinity DataIC50: 26nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544861(CHEMBL4634962 | US11292781, Compound T50)
Affinity DataIC50: 28nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as inhibition of T cell to Th17 differentiation by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544866(CHEMBL4643904 | US11292781, Compound T146)
Affinity DataIC50: 28nMAssay Description:Inverse agonist activity at full-length human RORgammat C285S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544866(CHEMBL4643904 | US11292781, Compound T146)
Affinity DataIC50: 30nMAssay Description:Inverse agonist activity at human full-length RORgammaT expressed in Jurkat cells co-transfected with 5 copies of ROR response element after 18 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544861(CHEMBL4634962 | US11292781, Compound T50)
Affinity DataIC50: 34nMAssay Description:Inverse agonist activity at full-length human RORgammat C345S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544862(CHEMBL4645611 | US11292781, Compound T83)
Affinity DataIC50: 35nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544874(CHEMBL4642370)
Affinity DataIC50: 36nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544866(CHEMBL4643904 | US11292781, Compound T146)
Affinity DataIC50: 37nMAssay Description:Inverse agonist activity at full-length human RORgammat C345S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544861(CHEMBL4634962 | US11292781, Compound T50)
Affinity DataIC50: 37nMAssay Description:Inverse agonist activity at full-length human RORgammat C320S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544861(CHEMBL4634962 | US11292781, Compound T50)
Affinity DataIC50: 37nMAssay Description:Inverse agonist activity at full-length human RORgammat C455S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544861(CHEMBL4634962 | US11292781, Compound T50)
Affinity DataIC50: 38nMAssay Description:Inverse agonist activity at full-length human RORgammat C285S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544861(CHEMBL4634962 | US11292781, Compound T50)
Affinity DataIC50: 38nMAssay Description:Inverse agonist activity at wild type full-length human RORgammat co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544866(CHEMBL4643904 | US11292781, Compound T146)
Affinity DataIC50: 38nMAssay Description:Inverse agonist activity at wild type full-length human RORgammat co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544861(CHEMBL4634962 | US11292781, Compound T50)
Affinity DataIC50: 39nMAssay Description:Inverse agonist activity at full-length human RORgammat C366S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544861(CHEMBL4634962 | US11292781, Compound T50)
Affinity DataIC50: 40nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544861(CHEMBL4634962 | US11292781, Compound T50)
Affinity DataIC50: 41nMAssay Description:Inverse agonist activity at full-length human RORgammat C278S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544861(CHEMBL4634962 | US11292781, Compound T50)
Affinity DataIC50: 44nMAssay Description:Inverse agonist activity at full-length human RORgammat C320A mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544863(CHEMBL4638990 | US11292781, Compound T147)
Affinity DataIC50: 46nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544860(CHEMBL4633864 | US11292781, Compound T56)
Affinity DataIC50: 46nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544866(CHEMBL4643904 | US11292781, Compound T146)
Affinity DataIC50: 47nMAssay Description:Inverse agonist activity at full-length human RORgammat C278S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544859(CHEMBL4633131 | US11292781, Compound T51)
Affinity DataIC50: 48nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544866(CHEMBL4643904 | US11292781, Compound T146)
Affinity DataIC50: 50nMAssay Description:Inverse agonist activity at full-length human RORgammat C393S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544866(CHEMBL4643904 | US11292781, Compound T146)
Affinity DataIC50: 50nMAssay Description:Inverse agonist activity at full-length human RORgammat C366S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544868(CHEMBL4644765)
Affinity DataIC50: 51nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544866(CHEMBL4643904 | US11292781, Compound T146)
Affinity DataIC50: 53nMAssay Description:Inverse agonist activity at full-length human RORgammat C455S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544861(CHEMBL4634962 | US11292781, Compound T50)
Affinity DataIC50: 58nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544866(CHEMBL4643904 | US11292781, Compound T146)
Affinity DataIC50: 58nMAssay Description:Inverse agonist activity at full-length human RORgammat C320S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544859(CHEMBL4633131 | US11292781, Compound T51)
Affinity DataIC50: 60nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544860(CHEMBL4633864 | US11292781, Compound T56)
Affinity DataIC50: 60nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544861(CHEMBL4634962 | US11292781, Compound T50)
Affinity DataIC50: 60nMAssay Description:Inverse agonist activity at full-length human RORgammat C393S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544861(CHEMBL4634962 | US11292781, Compound T50)
Affinity DataIC50: 62nMAssay Description:Inverse agonist activity at human full-length RORgammaT expressed in Jurkat cells co-transfected with 5 copies of ROR response element after 18 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544866(CHEMBL4643904 | US11292781, Compound T146)
Affinity DataIC50: 66nMAssay Description:Inverse agonist activity at full-length human RORgammat C320A mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544855(CHEMBL4633488 | US11292781, Compound T14)
Affinity DataIC50: 67nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544871(CHEMBL4647788 | US11292781, Compound T182)
Affinity DataIC50: 68nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544865(CHEMBL4638971 | US11292781, Compound T145)
Affinity DataIC50: 72nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544862(CHEMBL4645611 | US11292781, Compound T83)
Affinity DataIC50: 74nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544855(CHEMBL4633488 | US11292781, Compound T14)
Affinity DataIC50: 76nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544871(CHEMBL4647788 | US11292781, Compound T182)
Affinity DataIC50: 76nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544866(CHEMBL4643904 | US11292781, Compound T146)
Affinity DataIC50: 82nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544856(CHEMBL4640000 | US11292781, Compound T92)
Affinity DataIC50: 85nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544867(CHEMBL4642696)
Affinity DataIC50: 92nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544873(CHEMBL4639568 | US11292781, Compound T184)
Affinity DataIC50: 107nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544857(CHEMBL4636596 | US11292781, Compound T139)
Affinity DataIC50: 112nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544870(CHEMBL4642829 | US11292781, Compound T174)
Affinity DataIC50: 117nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544851(CHEMBL4647611 | US11292781, Compound T29)
Affinity DataIC50: 128nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544854(CHEMBL4646412 | US11292781, Compound T36)
Affinity DataIC50: 132nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
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