Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50018468
TargetTGF-beta receptor type-1(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM50608549(CHEMBL4303194)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of TbetaR-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM50402166(CHEMBL2207988)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human GST tagged TGFbeta 1 using 3,3',5,5'-tetramethylbenzidine as substrate incubated for 30 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human His-tagged TbetaR-1 assessed as inhibition of SMAD3 phosphorylation by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM50608550(CHEMBL1170377)
Affinity DataIC50: 12nMAssay Description:Inhibition of TbetaR-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM50320952(SB-525334 | 6-(2-tert-butyl-5-(6-methylpyridin-2-y...)
Affinity DataIC50: 14nMAssay Description:Inhibition of GST tagged TbetaR-1 (unknown origin) in the presence of 33 P-gamma ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM50184872(4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-pyridin-2-...)
Affinity DataIC50: 18nMAssay Description:Inhibition of TbetaR-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM50151347(2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-n...)
Affinity DataIC50: 23nMAssay Description:Inhibition of TbetaR-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM50132989(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quin...)
Affinity DataIC50: 25nMAssay Description:Inhibition of TbetaR-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM50608551(SB-505124 | CHEMBL1824446)
Affinity DataIC50: 47nMAssay Description:Inhibition of GST tagged TbetaR-1 (unknown origin) by Westernblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM50204834(2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pterid...)
Affinity DataIC50: 48nMAssay Description:Inhibition of TbetaR-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM50015640(LY-2157299 | GALUNISERTIB)
Affinity DataIC50: 56nMAssay Description:Inhibition of TbetaR-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM50110208(SB-431542 | cid_4521392 | 4-(5-(benzo[d][1,3]dioxo...)
Affinity DataIC50: 94nMAssay Description:Inhibition of TbetaR-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM50402166(CHEMBL2207988)
Affinity DataIC50: 836nMAssay Description:Inhibition of human GST tagged ALK3 incubated for 30 mins in presence of ATP by QSSA Kit methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM21509(4-[2-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]...)
Affinity DataKi:  38nMAssay Description:Inhibition of TbetaR-1 (unknown origin) assessed as inhibition constant by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTGF-beta receptor type-2(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM21509(4-[2-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]...)
Affinity DataKi:  300nMAssay Description:Inhibition of TbetaR-2 (unknown origin) assessed as inhibition constant by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed