Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with all data for entry = 50007988
TargetEndoplasmic reticulum aminopeptidase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514671(CHEMBL4532803)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length C-terminal His6-tagged ERAP1 (unknown origin)-mediated antigenic epitope destruction assessed as inhibition of trimming of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514671(CHEMBL4532803)
Affinity DataIC50: 1.00E+3nMAssay Description:Activation of full length C-terminal His6-tagged ERAP1 (unknown origin)-mediated fluorogenic Leu-AMC substrate hydrolysis after 60 mins by Rapidfire-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514671(CHEMBL4532803)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of full length C-terminal His6-tagged ERAP1 (unknown origin)-mediated chicken ovalbumin antigenic epitope processing assessed as reduction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514671(CHEMBL4532803)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ERAP1-mediated antigen epitope presentation in human HeLa cells transfected with Bacmam virus containing mouse MHC-1 allele H-2 Kb, bet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514671(CHEMBL4532803)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of full length C-terminal His6-tagged ERAP1 (unknown origin)-mediated chicken ovalbumin antigenic epitope processing assessed as reduction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514671(CHEMBL4532803)
Affinity DataIC50: 1.58E+5nMAssay Description:Activation of ERAP2 (unknown origin)-mediated Arg-AMC substrate hydrolysis after 60 mins by Rapidfire-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor antagonist protein(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514671(CHEMBL4532803)
Affinity DataIC50: 2.51E+5nMAssay Description:Activation of IRAP (unknown origin)-mediated Leu-AMC substrate hydrolysis after 60 mins by Rapidfire-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed