Compile Data Set for Download or QSAR
Report error Found 66 Enz. Inhib. hit(s) with all data for entry = 50009333
TargetTyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387821(US10294226, Compound Ex. 4 | N-(2-Cyanoethyl)-2-(1...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of JAK1-JH1/JH2 domain (574 to 1154 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527405(CHEMBL4456630 | US10981911, Example 26)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of JAK1-JH1/JH2 domain (574 to 1154 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387815(US10294226, Compound A | US10487083, Example A | U...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of JAK2-JH1/JH2 domain (532 to 1132 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387815(US10294226, Compound A | US10487083, Example A | U...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of JAK1-JH1/JH2 domain (574 to 1154 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387824(US10294226, Compound Ex. 7 | N-(2-Cyano-2-methylpr...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of JAK1-JH1/JH2 domain (574 to 1154 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527410(CHEMBL4439418 | US10981911, Example 57)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of JAK1-JH1/JH2 domain (574 to 1154 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527404(CHEMBL4514898 | US10981911, Example 62)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of JAK1-JH1/JH2 domain (574 to 1154 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387818(US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of JAK1-JH1/JH2 domain (574 to 1154 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527406(CHEMBL4588333 | US10981911, Example 45)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of JAK1-JH1/JH2 domain (574 to 1154 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527409(CHEMBL4447497 | US10981911, Example 58)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of JAK1-JH1/JH2 domain (574 to 1154 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527408(CHEMBL4437638 | US10981911, Example 94)
Affinity DataIC50: 0.920nMAssay Description:Inhibition of JAK1-JH1/JH2 domain (574 to 1154 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527407(CHEMBL4582390 | US10981911, Example 33)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of JAK1-JH1/JH2 domain (574 to 1154 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of JAK1-JH1/JH2 domain (574 to 1154 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527404(CHEMBL4514898 | US10981911, Example 62)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of JAK2-JH1/JH2 domain (532 to 1132 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527406(CHEMBL4588333 | US10981911, Example 45)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL2-induced STAT5 phosphorylation pre-incubated for 30 mins before IL2 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527409(CHEMBL4447497 | US10981911, Example 58)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of JAK2-JH1/JH2 domain (532 to 1132 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK2-JH1/JH2 domain (532 to 1132 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387824(US10294226, Compound Ex. 7 | N-(2-Cyano-2-methylpr...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of JAK2-JH1/JH2 domain (532 to 1132 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527410(CHEMBL4439418 | US10981911, Example 57)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of JAK2-JH1/JH2 domain (532 to 1132 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527405(CHEMBL4456630 | US10981911, Example 26)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of JAK2-JH1/JH2 domain (532 to 1132 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387821(US10294226, Compound Ex. 4 | N-(2-Cyanoethyl)-2-(1...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of JAK2-JH1/JH2 domain (532 to 1132 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL2-induced STAT5 phosphorylation pre-incubated for 30 mins before IL2 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527410(CHEMBL4439418 | US10981911, Example 57)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL2-induced STAT5 phosphorylation pre-incubated for 30 mins before IL2 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527407(CHEMBL4582390 | US10981911, Example 33)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of JAK2-JH1/JH2 domain (532 to 1132 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of JAK3-JH1/JH2 domain (512 to 1124 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387818(US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of JAK2-JH1/JH2 domain (532 to 1132 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527406(CHEMBL4588333 | US10981911, Example 45)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of JAK2-JH1/JH2 domain (532 to 1132 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527408(CHEMBL4437638 | US10981911, Example 94)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL2-induced STAT5 phosphorylation pre-incubated for 30 mins before IL2 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387824(US10294226, Compound Ex. 7 | N-(2-Cyano-2-methylpr...)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL2-induced STAT5 phosphorylation pre-incubated for 30 mins before IL2 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387815(US10294226, Compound A | US10487083, Example A | U...)
Affinity DataIC50: 12nMAssay Description:Inhibition of JAK3-JH1/JH2 domain (512 to 1124 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387818(US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...)
Affinity DataIC50: 22nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL2-induced STAT5 phosphorylation pre-incubated for 30 mins before IL2 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527408(CHEMBL4437638 | US10981911, Example 94)
Affinity DataIC50: 22nMAssay Description:Inhibition of JAK2-JH1/JH2 domain (532 to 1132 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 26nMAssay Description:Inhibition of JAK1/Tyk2 in human PBMC assessed as reduction in IFNalpha-induced STAT4 phosphorylation pre-incubated for 30 mins before IFNalpha stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527406(CHEMBL4588333 | US10981911, Example 45)
Affinity DataIC50: 28nMAssay Description:Inhibition of JAK2/JAK2 in human PBMC assessed as reduction in GM-CSF-induced STAT5 phosphorylation pre-incubated for 30 mins before GM-CSF stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527404(CHEMBL4514898 | US10981911, Example 62)
Affinity DataIC50: 31nMAssay Description:Inhibition of JAK3-JH1/JH2 domain (512 to 1124 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387821(US10294226, Compound Ex. 4 | N-(2-Cyanoethyl)-2-(1...)
Affinity DataIC50: 36nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL2-induced STAT5 phosphorylation pre-incubated for 30 mins before IL2 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 38nMAssay Description:Inhibition of JAK2/JAK2 in human PBMC assessed as reduction in GM-CSF-induced STAT5 phosphorylation pre-incubated for 30 mins before GM-CSF stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527410(CHEMBL4439418 | US10981911, Example 57)
Affinity DataIC50: 39nMAssay Description:Inhibition of JAK2/JAK2 in human PBMC assessed as reduction in GM-CSF-induced STAT5 phosphorylation pre-incubated for 30 mins before GM-CSF stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387824(US10294226, Compound Ex. 7 | N-(2-Cyano-2-methylpr...)
Affinity DataIC50: 39nMAssay Description:Inhibition of JAK1/Tyk2 in human PBMC assessed as reduction in IFNalpha-induced STAT4 phosphorylation pre-incubated for 30 mins before IFNalpha stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527405(CHEMBL4456630 | US10981911, Example 26)
Affinity DataIC50: 47nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL2-induced STAT5 phosphorylation pre-incubated for 30 mins before IL2 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527404(CHEMBL4514898 | US10981911, Example 62)
Affinity DataIC50: 54nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL2-induced STAT5 phosphorylation pre-incubated for 30 mins before IL2 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387818(US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...)
Affinity DataIC50: 54nMAssay Description:Inhibition of JAK1/Tyk2 in human PBMC assessed as reduction in IFNalpha-induced STAT4 phosphorylation pre-incubated for 30 mins before IFNalpha stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527409(CHEMBL4447497 | US10981911, Example 58)
Affinity DataIC50: 56nMAssay Description:Inhibition of JAK3-JH1/JH2 domain (512 to 1124 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387821(US10294226, Compound Ex. 4 | N-(2-Cyanoethyl)-2-(1...)
Affinity DataIC50: 65nMAssay Description:Inhibition of JAK1/Tyk2 in human PBMC assessed as reduction in IFNalpha-induced STAT4 phosphorylation pre-incubated for 30 mins before IFNalpha stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527410(CHEMBL4439418 | US10981911, Example 57)
Affinity DataIC50: 69nMAssay Description:Inhibition of JAK3-JH1/JH2 domain (512 to 1124 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387824(US10294226, Compound Ex. 7 | N-(2-Cyano-2-methylpr...)
Affinity DataIC50: 69nMAssay Description:Inhibition of JAK2/JAK2 in human PBMC assessed as reduction in GM-CSF-induced STAT5 phosphorylation pre-incubated for 30 mins before GM-CSF stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527407(CHEMBL4582390 | US10981911, Example 33)
Affinity DataIC50: 74nMAssay Description:Inhibition of JAK3-JH1/JH2 domain (512 to 1124 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387818(US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...)
Affinity DataIC50: 83nMAssay Description:Inhibition of JAK2/JAK2 in human PBMC assessed as reduction in GM-CSF-induced STAT5 phosphorylation pre-incubated for 30 mins before GM-CSF stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387821(US10294226, Compound Ex. 4 | N-(2-Cyanoethyl)-2-(1...)
Affinity DataIC50: 90nMAssay Description:Inhibition of JAK2/JAK2 in human PBMC assessed as reduction in GM-CSF-induced STAT5 phosphorylation pre-incubated for 30 mins before GM-CSF stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM387818(US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...)
Affinity DataIC50: 92nMAssay Description:Inhibition of JAK3-JH1/JH2 domain (512 to 1124 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
Displayed 1 to 50 (of 66 total ) | Next | Last >>
Jump to: