Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 50010797
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50197073(PD-0305970 | 3-amino-7-{(R)-3-[(S)-1-amino-ethyl]-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA gyrase AB supercoiling activity using relaxed DNA as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542206(CHEMBL4640061)
Affinity DataIC50: 430nMAssay Description:Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA gyrase AB supercoiling activity using relaxed DNA as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM21690(Ciprinol | 1-cyclopropyl-6-fluoro-4-oxo-7-(piperaz...)
Affinity DataIC50: 490nMAssay Description:Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA gyrase AB supercoiling activity using relaxed DNA as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542207(CHEMBL4634552)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA gyrase AB supercoiling activity using relaxed DNA as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542205(CHEMBL4643875)
Affinity DataIC50: 2.91E+3nMAssay Description:Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA gyrase AB supercoiling activity using relaxed DNA as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542206(CHEMBL4640061)
Affinity DataIC50: 4.88E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells measured after 10 mins by manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542207(CHEMBL4634552)
Affinity DataIC50: 1.14E+5nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells measured for 10 mins by QPatch automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542208(CHEMBL4638390)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells by QPatch automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed