Compile Data Set for Download or QSAR
Report error Found 69 Enz. Inhib. hit(s) with all data for entry = 50013009
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562071(CHEMBL319408)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562070(CHEMBL17612)
Affinity DataIC50: 0.0540nMAssay Description:Inhibition of HIV1 protease using H-Val-Ser-Gln-Am-(L-b-naphthyl-alanine)-Pro-Ile-Val-OH as substrate by HPLC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetIntegrin alpha-4/beta-1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562072(CHEMBL4798264)
Affinity DataIC50: 0.0700nMAssay Description:Displacement of 125I-VCAM-Ig from VLA4 in human Jurkat cells incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50001465(2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionyl...)
Affinity DataEC50:  0.0800nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetIntegrin alpha-4/beta-1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50105397((S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-azeti...)
Affinity DataIC50: 0.0800nMAssay Description:Displacement of 125I-VCAM-Ig from VLA4 in human Jurkat cells incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50241259(LY-411575 | (2S)-2-((S)-2-(3,5-difluorophenyl)-2-h...)
Affinity DataIC50: 0.0820nMAssay Description:Inhibition of gamma secretase in HEK293 cells assessed as reduction in amyloid beta40 level incubated for 4 hrs by electrochemiluminescence detection...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetIntegrin alpha-4/beta-1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50144749((S)-2-[((S)-1-Benzenesulfonyl-azetidine-2-carboxim...)
Affinity DataIC50: 0.100nMAssay Description:Displacement of 125I-VCAM-Ig from VLA4 in human Jurkat cells incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetIntegrin alpha-4/beta-1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50144760((S)-2-{[(S)-1-Benzenesulfonyl-N-(2,2,2-trifluoro-e...)
Affinity DataIC50: 0.130nMAssay Description:Displacement of 125I-VCAM-Ig from VLA4 in human Jurkat cells incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50213021(CHEBI:63621 | Fortovase | Invirase | Ro-31-8959 | ...)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of HIV1 protease using H-Val-Ser-Gln-Am-(L-b-naphthyl-alanine)-Pro-Ile-Val-OH as substrate by HPLC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562066(CHEMBL4756661)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptor expressed in HEK cells by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562067(CHEMBL4749288)
Affinity DataKi:  0.690nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as effect on intracellular calcium level by FLOU-4 dye based fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562069(CHEMBL4785595)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of TNF-induced MMP2 isolated from human HT-1080 cell medium by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562069(CHEMBL4785595)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PMA-induced human skin fibroblast derived MMP1 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50072566((2R,3S)-2-Allyl-N*4*-[(S)-1-benzyl-2-(1H-indol-3-y...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of TNF-induced MMP2 isolated from human HT-1080 cell medium by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50072566((2R,3S)-2-Allyl-N*4*-[(S)-1-benzyl-2-(1H-indol-3-y...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PMA-induced human skin fibroblast derived MMP1 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50249592(CHEMBL4061179)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptor expressed in HEK cells by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50001465(2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionyl...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562068(CHEMBL4791227)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of TNF-induced MMP2 isolated from human HT-1080 cell medium by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMatrilysin(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50072566((2R,3S)-2-Allyl-N*4*-[(S)-1-benzyl-2-(1H-indol-3-y...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human MMP7 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562068(CHEMBL4791227)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of PMA-induced human skin fibroblast derived MMP1 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNeprilysin(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50006115((RETRO)N-(1-Mercaptomethyl-2-phenyl-ethyl)-malonam...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of NEP 24.11 (unknown origin) by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetStromelysin-1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50072566((2R,3S)-2-Allyl-N*4*-[(S)-1-benzyl-2-(1H-indol-3-y...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human MMP3 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50001465(2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionyl...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of [3H]-Deltorphin 2 binding to mouse delta opioid receptor expressed in rat GH3 cell membranes by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562065(CHEMBL4745169)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptor expressed in HEK cells by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562075(CHEMBL4758323)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50001465(2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionyl...)
Affinity DataKi:  6.90nMAssay Description:Inhibition of [3H]-Deltorphin 2 binding to mouse delta opioid receptor expressed in HEK293 cell membranes incubated for 60 mins by Cheng-Prusoff anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetStromelysin-1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562069(CHEMBL4785595)
Affinity DataIC50: 10nMAssay Description:Inhibition of human MMP3 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMatrilysin(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562068(CHEMBL4791227)
Affinity DataIC50: 11nMAssay Description:Inhibition of human MMP7 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMatrilysin(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562069(CHEMBL4785595)
Affinity DataIC50: 11nMAssay Description:Inhibition of human MMP7 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetStromelysin-1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562068(CHEMBL4791227)
Affinity DataIC50: 12nMAssay Description:Inhibition of human MMP3 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562077(CHEMBL4754992)
Affinity DataKi:  12nMAssay Description:Inhibition of [3H]-Deltorphin 2 binding to mouse delta opioid receptor expressed in rat GH3 cell membranes by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50002477((S)-3-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at CCKBR in human NCI-H345 cells assessed as calcium releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562078(CHEMBL98593)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]-Deltorphin 2 binding to mouse delta opioid receptor expressed in rat GH3 cell membranes by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562074(CHEMBL312911)
Affinity DataIC50: 20nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50290520(((R)-1-{(S)-1-[(2R,3S)-3-(2-tert-Butylsulfamoyl-et...)
Affinity DataIC50: 20nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562076(CHEMBL4783390)
Affinity DataIC50: 30nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562066(CHEMBL4756661)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK cells by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50517920(CHEMBL4572725)
Affinity DataKi:  34nMAssay Description:Inhibition of [3H]-Deltorphin 2 binding to mouse delta opioid receptor expressed in rat GH3 cell membranes by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562078(CHEMBL98593)
Affinity DataEC50:  35nMAssay Description:Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electric-field induced measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562080(CHEMBL4791620)
Affinity DataEC50:  40nMAssay Description:Agonist activity at CCKBR in human NCI-H345 cells assessed as calcium releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50517888(CHEMBL4442842)
Affinity DataKi:  43nMAssay Description:Inhibition of [3H]-Deltorphin 2 binding to mouse delta opioid receptor expressed in HEK293 cell membranes incubated for 60 mins by Cheng-Prusoff anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50517889(CHEMBL4567560)
Affinity DataKi:  47nMAssay Description:Inhibition of [3H]-Deltorphin 2 binding to mouse delta opioid receptor expressed in rat GH3 cell membranes by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataEC50:  60nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50001465(2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionyl...)
Affinity DataEC50:  74nMAssay Description:Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electric-field induced measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50001465(2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionyl...)
Affinity DataEC50:  80nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562077(CHEMBL4754992)
Affinity DataEC50:  140nMAssay Description:Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electric-field induced measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562081(CHEMBL4784305)
Affinity DataEC50:  150nMAssay Description:Agonist activity at CCKBR in human NCI-H345 cells assessed as calcium releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50146642([(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarb...)
Affinity DataIC50: 160nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNeprilysin(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50024095((R) N-(1-Mercaptomethyl-2-phenyl-ethyl)-malonamic ...)
Affinity DataKi:  210nMAssay Description:Inhibition of NEP 24.11 (unknown origin) by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
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