Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50018500
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50546219(CHEMBL4752026 | US11596633, Compound B | US1170239...)
Affinity DataIC50: 0.583nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 318nMAssay Description:Inhibition of recombinant GST-fused human SHP2 (205 to 593 residues) using DiFMUP as substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 355nMAssay Description:Inhibition of recombinant GST-fused human SHP1 (205 to 597 residues) using DiFMUP as substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM152151(US8987474, HL1-056 (NSC-117199) )
Affinity DataIC50: 800nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 1.69E+3nMAssay Description:Inhibition of recombinant GST-fused human PTP1B (1 to 435 residues) using DiFMUP as substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50342004(4-(2-(3-(4-nitrophenyl)-5-oxo-1-phenyl-1H-pyrazol-...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50593513(CHEMBL5184184)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of SHP2 (unknown origin) using pNPP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50546226(CHEMBL4778434)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of recombinant His-tag fused full length human SHP2 expressed in Escherichia coli BL21 USING pNPP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50342004(4-(2-(3-(4-nitrophenyl)-5-oxo-1-phenyl-1H-pyrazol-...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50342004(4-(2-(3-(4-nitrophenyl)-5-oxo-1-phenyl-1H-pyrazol-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50546210(CHEMBL1434615)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of SHP2 ( 1 to 525 residues) (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed