Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50012849
TargetNAD(+) hydrolase SARM1(Human)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50203126(Berberinechloride | 9,10-Dimethoxy-5,6-dihydro-[1,...)
Affinity DataIC50: 7.70E+4nMAssay Description:Inhibition of recombinant human SARM1 SAM1-2-TIR domains (412 to 724 residues) expressed in Expi293 cells lysates using ENAD as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50420350(Actin-N | Furacilin | Furacin | Furazone | Nitrofu...)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50203126(Berberinechloride | 9,10-Dimethoxy-5,6-dihydro-[1,...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of recombinant human SARM1 SAM1-2-TIR domains (412 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50203126(Berberinechloride | 9,10-Dimethoxy-5,6-dihydro-[1,...)
Affinity DataIC50: 1.40E+5nMAssay Description:Inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50203126(Berberinechloride | 9,10-Dimethoxy-5,6-dihydro-[1,...)
Affinity DataIC50: 1.40E+5nMAssay Description:Inhibition of purified human SARM1 TIR domain (561 to 724 residues) using ENAD as substrate preincubated for 20 mins followed by ENAD addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50248132(DOXYCYCLINE HYDROCHLORIDE | CHEBI:652992 | Doxycyc...)
Affinity DataIC50: 1.45E+5nMAssay Description:Inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50420356(NC 150 | PHENAZOPYRIDINE HYDROCHLORIDE)
Affinity DataIC50: 1.45E+5nMAssay Description:Inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50420356(NC 150 | PHENAZOPYRIDINE HYDROCHLORIDE)
Affinity DataKi:  7.00E+4nMAssay Description:Competitive inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50420350(Actin-N | Furacilin | Furacin | Furazone | Nitrofu...)
Affinity DataKi:  1.20E+5nMAssay Description:Noncompetitive inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50203126(Berberinechloride | 9,10-Dimethoxy-5,6-dihydro-[1,...)
Affinity DataKi:  1.30E+5nMAssay Description:Noncompetitive inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50248132(DOXYCYCLINE HYDROCHLORIDE | CHEBI:652992 | Doxycyc...)
Affinity DataKi:  2.80E+5nMAssay Description:Noncompetitive inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed