Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 50012078
TargetFarnesyl pyrophosphate synthase(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50553948(CHEMBL1160572)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of N-terminal hexaHis-tagged human FPPS (6 to 353 residues) expressed in Escherichia coli using GPP and IPP as substrate by enzyme coupled...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50553949(CHEMBL4759133)
Affinity DataIC50: 1.77E+5nMAssay Description:Inhibition of N-terminal hexaHis-tagged human FPPS (6 to 353 residues) expressed in Escherichia coli using GPP and IPP as substrate by enzyme coupled...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50553947(CHEMBL4795079)
Affinity DataIC50: 2.33E+5nMAssay Description:Inhibition of N-terminal hexaHis-tagged human FPPS (6 to 353 residues) expressed in Escherichia coli using GPP and IPP as substrate by enzyme coupled...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Leishmania major)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM12578(CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...)
Affinity DataKi:  10nMAssay Description:Inhibition of recombinant Leishmania major FPPS expressed in Escherichia coli BL21(DE3) using GPP and [14C]IPP as substrate incubated for 15 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Leishmania major)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM12576(JMC515594 Compound 64 | Risdronate | CHEMBL923 | R...)
Affinity DataKi:  16nMAssay Description:Inhibition of recombinant Leishmania major FPPS expressed in Escherichia coli BL21(DE3) using GPP and [14C]IPP as substrate incubated for 15 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Leishmania major)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50553950(CHEMBL4782875)
Affinity DataKi:  86nMAssay Description:Inhibition of recombinant Leishmania major FPPS expressed in Escherichia coli BL21(DE3) using GPP and [14C]IPP as substrate incubated for 15 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Leishmania major)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM25313((4-amino-1-hydroxy-1-phosphonobutyl)phosphonic aci...)
Affinity DataKi:  91nMAssay Description:Inhibition of recombinant Leishmania major FPPS expressed in Escherichia coli BL21(DE3) using GPP and [14C]IPP as substrate incubated for 15 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Leishmania major)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50113286(undecane-1-hydroxy-1,1-bisphosphonate | (1-Hydroxy...)
Affinity DataKi:  330nMAssay Description:Inhibition of recombinant Leishmania major FPPS expressed in Escherichia coli BL21(DE3) using GPP and [14C]IPP as substrate incubated for 15 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed