Compile Data Set for Download or QSAR
Report error Found 183 Enz. Inhib. hit(s) with all data for entry = 50012093
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50534361(CHEMBL4445443)
Affinity DataEC50:  305nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as effect on amyloid beta38 level by meso scale discove...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554085(CHEMBL4750723)
Affinity DataEC50:  187nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as effect on amyloid beta38 level by meso scale discove...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554103(CHEMBL4758131)
Affinity DataEC50:  202nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as effect on amyloid beta38 level by meso scale discove...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554085(CHEMBL4750723)
Affinity DataIC50: 14nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as effect on amyloid beta42 level by meso scale discove...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554103(CHEMBL4758131)
Affinity DataIC50: 19nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as effect on amyloid beta42 level by meso scale discove...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554106(CHEMBL4799797)
Affinity DataIC50: 21nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554098(CHEMBL4749020)
Affinity DataIC50: 32nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554112(CHEMBL4745955)
Affinity DataIC50: 32nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554103(CHEMBL4758131)
Affinity DataIC50: 33nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554108(CHEMBL4777391)
Affinity DataIC50: 36nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554090(CHEMBL4760389)
Affinity DataIC50: 38nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554094(CHEMBL4794797)
Affinity DataIC50: 40nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554095(CHEMBL4786740)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554074(CHEMBL4765020)
Affinity DataIC50: 46nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554085(CHEMBL4750723)
Affinity DataIC50: 47nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554073(CHEMBL4744393)
Affinity DataIC50: 48nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554089(CHEMBL4777113)
Affinity DataIC50: 50nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554109(CHEMBL4761020)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554086(CHEMBL4746048)
Affinity DataIC50: 57nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554099(CHEMBL4763513)
Affinity DataIC50: 58nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50534361(CHEMBL4445443)
Affinity DataIC50: 58nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as effect on amyloid beta42 level by meso scale discove...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50534361(CHEMBL4445443)
Affinity DataIC50: 60nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554105(CHEMBL4762589)
Affinity DataIC50: 62nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554078(CHEMBL4780956)
Affinity DataIC50: 63nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50533496(CHEMBL4438330)
Affinity DataIC50: 63nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554076(CHEMBL4795963)
Affinity DataIC50: 64nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554093(CHEMBL4794750)
Affinity DataIC50: 64nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554107(CHEMBL4759910)
Affinity DataIC50: 64nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554075(CHEMBL4754724)
Affinity DataIC50: 71nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554111(CHEMBL4798079)
Affinity DataIC50: 72nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554095(CHEMBL4786740)
Affinity DataIC50: 73nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554096(CHEMBL4751736)
Affinity DataIC50: 73nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554109(CHEMBL4761020)
Affinity DataIC50: 75nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554102(CHEMBL4741605)
Affinity DataIC50: 80nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554077(CHEMBL4797165)
Affinity DataIC50: 83nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554059(CHEMBL4746523)
Affinity DataIC50: 89nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554104(CHEMBL4783910)
Affinity DataIC50: 90nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554071(CHEMBL4758548)
Affinity DataIC50: 96nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554092(CHEMBL4748419)
Affinity DataIC50: 100nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554085(CHEMBL4750723)
Affinity DataIC50: 100nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as effect on amyloid beta40 level by meso scale discove...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554079(CHEMBL4781159)
Affinity DataIC50: 102nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554080(CHEMBL4796849)
Affinity DataIC50: 102nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50534361(CHEMBL4445443)
Affinity DataIC50: 104nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as effect on amyloid beta40 level by meso scale discove...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554064(CHEMBL4745663)
Affinity DataIC50: 105nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554110(CHEMBL4747572)
Affinity DataIC50: 109nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554072(CHEMBL4752898)
Affinity DataIC50: 114nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554084(CHEMBL4783110)
Affinity DataIC50: 126nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554100(CHEMBL4741380)
Affinity DataIC50: 126nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554068(CHEMBL4747005)
Affinity DataIC50: 136nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554087(CHEMBL4744088)
Affinity DataIC50: 144nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
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