Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50012107
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM283216(US9573930, Example 86 | US10023543, Example 86 | 4...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM501809(4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM283129(US9573930, Example 2 | US10023543, Example 2 | 4-[...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM283200(US9573930, Example 5 | US10023543, Example 5 | 4-[...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM50554230(CHEMBL4748670)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM501778(4-[6-(4-aminopiperidin-1-yl)-4- methyl-3-(4-methy...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM283128(US9573930, Example 1 | US10023543, Example 1 | 4-(...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM50554231(CHEMBL4796870)
Affinity DataIC50: 2nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM283216(US9573930, Example 86 | US10023543, Example 86 | 4...)
Affinity DataEC50:  3nMAssay Description:Inhibition of LSD1 in human NCI-H69 cells assessed as suppression of GRP mRNA expression incubated for 4 days by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM301089(4-[2-(4-aminopiperidin-1-yl)-5-(4- methylphenyl)py...)
Affinity DataIC50: 3nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM283216(US9573930, Example 86 | US10023543, Example 86 | 4...)
Affinity DataEC50:  4nMAssay Description:Inhibition of LSD1 in human NCI-H1417 cells assessed as suppression of GRP mRNA expression incubated for 4 days by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM283216(US9573930, Example 86 | US10023543, Example 86 | 4...)
Affinity DataEC50:  6nMAssay Description:Inhibition of LSD1 in human NCI-H1417 cells assessed as suppression of GRP mRNA expression incubated for 12 days by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM283216(US9573930, Example 86 | US10023543, Example 86 | 4...)
Affinity DataIC50: 7nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of cell differentiation by measuring CD11b expression incubated for 96 hrs by FACS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM501810(4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p...)
Affinity DataIC50: 11nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM283128(US9573930, Example 1 | US10023543, Example 1 | 4-(...)
Affinity DataIC50: 14nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of cell differentiation by measuring CD11b expression incubated for 96 hrs by FACS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM283129(US9573930, Example 2 | US10023543, Example 2 | 4-[...)
Affinity DataIC50: 14nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of cell differentiation by measuring CD11b expression incubated for 96 hrs by FACS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM283200(US9573930, Example 5 | US10023543, Example 5 | 4-[...)
Affinity DataIC50: 14nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of cell differentiation by measuring CD11b expression incubated for 96 hrs by FACS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM501809(4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p...)
Affinity DataIC50: 18nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of cell differentiation by measuring CD11b expression incubated for 96 hrs by FACS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM50554231(CHEMBL4796870)
Affinity DataIC50: 28nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of cell differentiation by measuring CD11b expression incubated for 96 hrs by FACS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM301089(4-[2-(4-aminopiperidin-1-yl)-5-(4- methylphenyl)py...)
Affinity DataIC50: 28nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of cell differentiation by measuring CD11b expression incubated for 96 hrs by FACS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM501778(4-[6-(4-aminopiperidin-1-yl)-4- methyl-3-(4-methy...)
Affinity DataIC50: 47nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of cell differentiation by measuring CD11b expression incubated for 96 hrs by FACS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM50554230(CHEMBL4748670)
Affinity DataIC50: 73nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of cell differentiation by measuring CD11b expression incubated for 96 hrs by FACS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM501810(4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p...)
Affinity DataIC50: 120nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of cell differentiation by measuring CD11b expression incubated for 96 hrs by FACS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM283216(US9573930, Example 86 | US10023543, Example 86 | 4...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed