Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50013678
TargetFocal adhesion kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50568532(CHEMBL4742157)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM418609(N-methyl-4-({4-[({2- [methyl(methylsulfonyl)amino]...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM418609(N-methyl-4-({4-[({2- [methyl(methylsulfonyl)amino]...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human pyk2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50554439(CHEMBL4752642)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50318884(CHEMBL1084546 | CHEMBL2430359 | N-methyl-N-(3-((2-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of pyk2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFocal adhesion kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50318884(CHEMBL1084546 | CHEMBL2430359 | N-methyl-N-(3-((2-...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of FAK (unknown origin) (410 to 689 residues) assessed as reduction in poly(Glu-Tyr) phosphorylation by absorbance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFocal adhesion kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50440659(CHEMBL2430358)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of GST-fused FAK (411 to 686 residues) (unknown origin) expressed in sf9 cells using poly(Glu:Tyr) (4:1) copolymer as substrate by spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50246187(5-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)
Affinity DataIC50: 4nMAssay Description:Inhibition of FAK (unknown origin) (410 to 689 residues) assessed as reduction in poly(Glu-Tyr) phosphorylation using poly (Glu,Tyr) as substrate by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462632(CHEMBL545839)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50568532(CHEMBL4742157)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of FAK in human U87MG cells assessed as reduction in phosphorylation at Y397 residue incubated for 30 mins by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50568532(CHEMBL4742157)
Affinity DataIC50: 12nMAssay Description:Inhibition of FAK in human A549 cells assessed as reduction in phosphorylation at Y397 residue incubated for 30 mins by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50568532(CHEMBL4742157)
Affinity DataIC50: 15nMAssay Description:Inhibition of FAK in human OVCAR8 cells assessed as reduction in phosphorylation at Y397 residue incubated for 30 mins by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462632(CHEMBL545839)
Affinity DataIC50: 33nMAssay Description:Inhibition of pyk2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetInsulin receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462632(CHEMBL545839)
Affinity DataIC50: 44nMAssay Description:Inhibition of InsR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462632(CHEMBL545839)
Affinity DataIC50: 140nMAssay Description:Inhibition of IGF-IR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50246187(5-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of pyk2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50520571(CHEMBL4447794)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of human FAK using poly (Glu,Tyr) as substrate by radiometric HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed