Compile Data Set for Download or QSAR
Report error Found 126 Enz. Inhib. hit(s) with all data for entry = 50011567
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM109773(US8609708, 74 Anabaseine)
Affinity DataEC50:  4.20E+3nMAssay Description:Agonist activity at rat alpha4beta2 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  1.40E+4nMAssay Description:Agonist activity at rat alpha4beta2 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548708(CHEMBL4779424)
Affinity DataEC50:  732nMAssay Description:Agonist activity at alpha4beta2 nAChR in rat thalamic synaptosomes assessed as increase in 86Rb effluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  591nMAssay Description:Agonist activity at alpha4beta2 nAChR in rat thalamic synaptosomes assessed as increase in 86Rb effluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50370573(US8609708, 91 Cotinine | COTININE | US10667515, Co...)
Affinity DataEC50:  2.10E+4nMAssay Description:Agonist activity at alpha4beta2 nAChR in rat frontal cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  77nMAssay Description:Agonist activity at alpha4beta2 nAChR in rat frontal cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548710(CHEMBL4745960)
Affinity DataEC50:  6.20E+3nMAssay Description:Agonist activity at human brain alpha4beta2 nAChR expressed in CHO cells by patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  800nMAssay Description:Agonist activity at human brain alpha4beta2 nAChR expressed in CHO cells by patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM109762(US8609708, 50 Anatabine)
Affinity DataEC50:  6.97E+4nMAssay Description:Agonist activity at human brain alpha7 nAChR expressed in Xenopus laevis oocytes assessed as peak responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548711(CHEMBL4761823)
Affinity DataEC50:  5.18E+4nMAssay Description:Agonist activity at human brain alpha7 nAChR expressed in Xenopus laevis oocytes assessed as peak responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM109762(US8609708, 50 Anatabine)
Affinity DataEC50:  2.65E+3nMAssay Description:Agonist activity at human brain alpha4beta2 nAChR expressed in Xenopus laevis oocytes assessed as peak responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548711(CHEMBL4761823)
Affinity DataEC50:  740nMAssay Description:Agonist activity at human brain alpha4beta2 nAChR expressed in Xenopus laevis oocytes assessed as peak responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM109767(US8609708, 59 Anabasine | US10667515, Compound (S)...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat brain alpha4beta2 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  1.90E+4nMAssay Description:Agonist activity at rat brain alpha4beta2 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM109767(US8609708, 59 Anabasine | US10667515, Compound (S)...)
Affinity DataEC50:  1.80E+4nMAssay Description:Agonist activity at rat brain alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50023328(Nornicotine | 3-Pyrrolidin-2-yl-pyridine | CHEMBL1...)
Affinity DataEC50:  6.14E+5nMAssay Description:Agonist activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50023328(Nornicotine | 3-Pyrrolidin-2-yl-pyridine | CHEMBL1...)
Affinity DataEC50:  3.75E+5nMAssay Description:Agonist activity at rat alpha4beta2 nAChR expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50023328(Nornicotine | 3-Pyrrolidin-2-yl-pyridine | CHEMBL1...)
Affinity DataEC50:  1.74E+4nMAssay Description:Agonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548686(CHEMBL4798987)
Affinity DataEC50:  310nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548687(CHEMBL4781983)
Affinity DataEC50:  1.01E+3nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM109773(US8609708, 74 Anabaseine)
Affinity DataEC50:  6.70E+3nMAssay Description:Agonist activity at rat alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  4.70E+4nMAssay Description:Agonist activity at rat alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548705(CHEMBL4740159)
Affinity DataIC50: 0.960nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by radioligand competition analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548704(CHEMBL4791046)
Affinity DataIC50: 3.90nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by radioligand competition analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548703(CHEMBL4793576)
Affinity DataIC50: 4.80nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by radioligand competition analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataIC50: 4.90nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by radioligand competition analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 10nMAssay Description:Inhibition of rat cortex homogenate acetylcholinesterase by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDopamine beta-hydroxylase(Bovine)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548688(CHEMBL4764135)
Affinity DataIC50: 39nMAssay Description:Inhibition of bovine adrenal medulla DBH incubated for 25 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Bovine)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50000439(CHEMBL24510 | 5-Butyl-pyridine-2-carboxylic acid |...)
Affinity DataIC50: 50nMAssay Description:Inhibition of bovine adrenal medulla DBH incubated for 25 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 74nMAssay Description:Inhibition of rat cortex homogenate BuChE by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50199522((+-)-HA | (1R,9R)-1-Amino-13-eth-(E)-ylidene-11-me...)
Affinity DataIC50: 82nMAssay Description:Inhibition of rat cortex homogenate acetylcholinesterase by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 93nMAssay Description:Inhibition of rat cortex homogenate acetylcholinesterase by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548702(CHEMBL4798114)
Affinity DataIC50: 260nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by radioligand competition analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 480nMAssay Description:Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate incubated for 30 mins by Ellman's coupled enzyme assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Electric eel)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548694(CHEMBL4757542)
Affinity DataIC50: 600nMAssay Description:Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548691(CHEMBL4752675)
Affinity DataIC50: 810nMAssay Description:Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate incubated for 30 mins by Ellman's coupled enzyme assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548696(CHEMBL4747899)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548698(CHEMBL4760427)
Affinity DataIC50: 2.57E+3nMAssay Description:Inhibition of acetylcholinesterase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548692(CHEMBL4791777)
Affinity DataIC50: 2.63E+3nMAssay Description:Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of rat cortex homogenate BuChE by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM10404(galantamine | (1S,12S,14R)-9-methoxy-4-methyl-11-o...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of acetylcholinesterase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548693(CHEMBL4759107)
Affinity DataIC50: 6.71E+3nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate preincubated for 20 mins followed by substrate addition and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548708(CHEMBL4779424)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]nicotine from 5-hydroxytryptamine receptor 3A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548708(CHEMBL4779424)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]nicotine from 5-hydroxytryptamine receptor 2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548708(CHEMBL4779424)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]nicotine from 5-hydroxytryptamine receptor 1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548708(CHEMBL4779424)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]nicotine from dopamine D3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548708(CHEMBL4779424)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]nicotine from Thromboxane A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548708(CHEMBL4779424)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]nicotine from NPY2R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548708(CHEMBL4779424)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]nicotine from B2 bradykinin receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548708(CHEMBL4779424)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]nicotine from Histamine H3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
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