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Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50013054
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM66082(SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM66082(SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human DHFR measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562445(CHEMBL4748139)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human DHFR measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562454(TCMDC-141974 | CHEMBL533684)
Affinity DataIC50: 25nMAssay Description:Inhibition of Leishmania major DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562450(CHEMBL4757974)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human DHFR measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562443(CHEMBL4759800)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human DHFR measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562444(CHEMBL4783671)
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant human DHFR measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562449(CHEMBL4745475)
Affinity DataIC50: 100nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562446(CHEMBL4752301)
Affinity DataIC50: 130nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562448(CHEMBL4779765)
Affinity DataIC50: 140nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562447(CHEMBL4761589)
Affinity DataIC50: 180nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562442(CHEMBL4748158)
Affinity DataIC50: 190nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562445(CHEMBL4748139)
Affinity DataIC50: 210nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562441(CHEMBL4791810)
Affinity DataIC50: 250nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562455(CHEMBL2005041)
Affinity DataIC50: 360nMAssay Description:Inhibition of Leishmania major DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562438(CHEMBL4743204)
Affinity DataIC50: 380nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562442(CHEMBL4748158)
Affinity DataIC50: 530nMAssay Description:Inhibition of recombinant human DHFR measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562444(CHEMBL4783671)
Affinity DataIC50: 530nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562441(CHEMBL4791810)
Affinity DataIC50: 810nMAssay Description:Inhibition of recombinant human DHFR measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562443(CHEMBL4759800)
Affinity DataIC50: 810nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562438(CHEMBL4743204)
Affinity DataIC50: 840nMAssay Description:Inhibition of recombinant human DHFR measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of recombinant human DHFR measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562449(CHEMBL4745475)
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of recombinant human DHFR measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562440(CHEMBL4754677)
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562447(CHEMBL4761589)
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of recombinant human DHFR measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562439(CHEMBL4750040)
Affinity DataIC50: 1.91E+3nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562446(CHEMBL4752301)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of recombinant human DHFR measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562448(CHEMBL4779765)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of recombinant human DHFR measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 2.05E+4nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562456(CHEMBL172782)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Leishmania major DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataKi:  10nMAssay Description:Inhibition of human DHFR assessed by NADPH oxidation measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataKi:  120nMAssay Description:Inhibition of Leishmania major DHFR assessed by NADPH oxidation measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50398388(CHEMBL2178604)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of Leishmania major DHFR assessed by NADPH oxidation measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50398388(CHEMBL2178604)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of human DHFR assessed by NADPH oxidation measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562452(CHEMBL4776197)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of Leishmania major DHFR assessed by NADPH oxidation measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562453(CHEMBL4783402)
Affinity DataKi:  2.40E+4nMAssay Description:Inhibition of human DHFR assessed by NADPH oxidation measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562451(CHEMBL4763597)
Affinity DataKi:  4.00E+4nMAssay Description:Inhibition of Leishmania major DHFR assessed by NADPH oxidation measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562452(CHEMBL4776197)
Affinity DataKi:  5.40E+4nMAssay Description:Inhibition of human DHFR assessed by NADPH oxidation measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562451(CHEMBL4763597)
Affinity DataKi:  5.60E+4nMAssay Description:Inhibition of human DHFR assessed by NADPH oxidation measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50562453(CHEMBL4783402)
Affinity DataKi:  7.50E+4nMAssay Description:Inhibition of Leishmania major DHFR assessed by NADPH oxidation measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed