Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50011605
Affinity DataKd: 51nMAssay Description:Binding affinity to GST-tagged GppNHp bound KRas G12V mutant (unknown origin) expressed in Escherichia coli C41(DE3) by 1H-CPMG NMR spectroscopyMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of KRas G12C mutant in human H358 cells assessed as reduction in ERK phosphorylation at T202/Y204 residue incubated for 24 hrs by immunobl...More data for this Ligand-Target Pair
Affinity DataEC50: 320nMAssay Description:Inhibition of KRas G12C mutant in human NCI-H1792 cells assessed as antiproliferative activity incubated for 3 days by CellTiter-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 450nMAssay Description:Inhibition of N-terminal 6His-tagged/C-terminal Avi-tagged biotinylated GDP-bound human KRas G12D mutant (1 to 169 residues) assessed as reduction in...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKd: 750nMAssay Description:Binding affinity to GTP-KRAS G12D (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 870nMAssay Description:Inhibition of C-terminal Avi-tagged biotinylated KRas G12D mutant (1 to 169 residues) (unknown origin) expressed in Escherichia coli assessed as redu...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of KRas G12C mutant in human H358 cells assessed as reduction in ERK phosphorylation at T202/Y204 residue incubated for 24 hrs by immunobl...More data for this Ligand-Target Pair
Affinity DataEC50: 1.58E+4nMAssay Description:Inhibition of KRas activation in HEK 293T-REx Flp-In cells harboring Venus-RBD-CRD/mCherry-CAAX assessed as reduction in Venus-RBD-CRD recruitment to...More data for this Ligand-Target Pair
Affinity DataKd: 2.00E+4nMAssay Description:Binding affinity to GCP-KRAS G12D (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataEC50: 2.66E+4nMAssay Description:Inhibition of KRas G12C mutant in human H358 cells assessed as antiproliferative activity incubated for 3 days by CellTiter-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of C-terminal Avi-tagged biotinylated KRas G12D mutant (1 to 169 residues) (unknown origin) expressed in Escherichia coli assessed as redu...More data for this Ligand-Target Pair
Affinity DataKd: 1.90E+5nMAssay Description:Binding affinity to 15N-labelled GDP bound KRas G12D mutant ( 1 to 169 residues) (unknown origin) expressed in Escherichia coli Rosetta 2 (DE3) cells...More data for this Ligand-Target Pair
Affinity DataKd: 3.40E+5nMAssay Description:Binding affinity to 15N-labelled GDP bound KRas G12D mutant ( 1 to 169 residues) (unknown origin) expressed in Escherichia coli Rosetta 2 (DE3) cells...More data for this Ligand-Target Pair
Affinity DataKd: 1.30E+6nMAssay Description:Binding affinity to 15N-labelled GDP bound KRas G12D mutant ( 1 to 169 residues) (unknown origin) expressed in Escherichia coli Rosetta 2 (DE3) cells...More data for this Ligand-Target Pair
