Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50017960
TargetProline--tRNA ligase(Plasmodium falciparum (isolate 3D7))
Panjab University

Curated by ChEMBL
LigandPNGBDBM50606503(CHEMBL322782)
Affinity DataEC50:  4nMAssay Description:Inhibition of Plasmodium falciparum 3D7 Prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAurora kinase B(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of Aurora B kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM4779(cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL3196...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 1nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Panjab University

Curated by ChEMBL
LigandPNGBDBM50011477(UR-9825 | ALBACONAZOLE)
Affinity DataIC50: 1nMAssay Description:Inhibition of Trypanosoma cruzi Sterol 14-alpha demethylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM29568([3H]-Minipress | [3H]-Furazosin | PRAZOSIN HYDROCH...)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at Adrenergic alpha-1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50088386(Bunazosin | Bunazosin HCl)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at Adrenergic alpha-1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50225112(43-715 | Arthrex | Proquazone)
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
LigandPNGBDBM50606506(CHEMBL2132175)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
LigandPNGBDBM50606507(CHEMBL5218611)
Affinity DataIC50: 3nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50033111(6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)p...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at Adrenergic alpha-1 receptor in human Prostate cell in presence of (125I)-Heat by Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetDihydrofolate reductase(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50027655(CHEBI:5847 | Raltitrexed | Tomudex | ZD-16 | ZD-16...)
Affinity DataIC50: 9nMAssay Description:Inhibition of DHFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetThymidylate synthase(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50027655(CHEBI:5847 | Raltitrexed | Tomudex | ZD-16 | ZD-16...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Thymidylate synthase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50606505(CHEMBL5218990)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate incubated for 10 mins in presence of ATP by caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50510888(CHEMBL4544826)
Affinity DataIC50: 12nMAssay Description:Inhibition of VEGFR-2 (unknown origin) using poly(Glu:Tyr)(4:1) and ATP as substrate by incubated for 1 hr by spectrophotometric based ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50536935(CHEMBL4533690)
Affinity DataIC50: 13nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
LigandPNGBDBM50460751(CHEMBL4229214)
Affinity DataIC50: 17nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50579500(CHEMBL4864729)
Affinity DataIC50: 19nMAssay Description:Inhibition of GST-tagged FLT-3 (unknown origin) (Tyr567-Ser993 residues) expressed in baculovirus infected Sf9 insect cells using GGMEDIYFEFMGGKKK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50606504(CHEMBL5218459)
Affinity DataIC50: 20nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate incubated for 10 mins in presence of ATP by caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50579500(CHEMBL4864729)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant GST Aurora A kinase (unknown origin) expressed in Sf9 insect cells incubated for 90 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50033110(N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methy...)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at Adrenergic alpha-1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 29nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 33nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50606504(CHEMBL5218459)
Affinity DataIC50: 50nMAssay Description:Inhibition of VEGFR-2 (unknown origin) using FAM-labeled peptide as substrate incubated for 10 mins in presence of ATP by caliper mobility shift assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50606507(CHEMBL5218611)
Affinity DataIC50: 50nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50536935(CHEMBL4533690)
Affinity DataIC50: 68nMAssay Description:Inhibition of PARP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50606505(CHEMBL5218990)
Affinity DataIC50: 80nMAssay Description:Inhibition of VEGFR-2 (unknown origin) using FAM-labeled peptide as substrate incubated for 10 mins in presence of ATP by caliper mobility shift assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAurora kinase B(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM14210(N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quin...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human Aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM14210(N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quin...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human Aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM7001(6-(3-aminophenyl)-N-tert-butyl-2-(trifluoromethyl)...)
Affinity DataIC50: 600nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetDihydrofolate reductase(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataKi:  0.0400nMAssay Description:Inhibition of DHFR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at 5-HT2A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed