Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50018219
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Escherichia coli (strain K12))
Birla Institute of Technology and Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50028309(Fosmidomycin Sodium)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant Escherichia coli DXR in presence of NADPH by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Escherichia coli (strain K12))
Birla Institute of Technology and Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50181153(FR-900098 | 3-(N-hydroxyformamido)propylphosphonic...)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant Escherichia coli DXR in presence of NADPH by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Escherichia coli (strain K12))
Birla Institute of Technology and Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50380000(CHEMBL258981)
Affinity DataIC50: 48nMAssay Description:Inhibition of Escherichia coli DXR assessed as inhibition constant pre-incubated for 2 mins in presence of NADPH by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Escherichia coli (strain K12))
Birla Institute of Technology and Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50028309(Fosmidomycin Sodium)
Affinity DataIC50: 49nMAssay Description:Inhibition of His-tagged Escherichia coli DXR using DXP as substrate incubated for 1 min in presence of NADPH by UV-Vis spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology and Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50028309(Fosmidomycin Sodium)
Affinity DataIC50: 80nMAssay Description:Inhibition of Mycobacterium tuberculosis DXR in presence of NADPH by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology and Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50181153(FR-900098 | 3-(N-hydroxyformamido)propylphosphonic...)
Affinity DataIC50: 160nMAssay Description:Inhibition of Mycobacterium tuberculosis DXR in presence of NADPH by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Escherichia coli (strain K12))
Birla Institute of Technology and Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50379999(CHEMBL1161784)
Affinity DataIC50: 170nMAssay Description:Inhibition of Escherichia coli DXR assessed as inhibition constant pre-incubated for 2 mins in presence of NADPH by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Escherichia coli (strain K12))
Birla Institute of Technology and Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50135835([(ISOQUINOLIN-1-YLAMINO)-PHOSPHONO-METHYL]-PHOSPHO...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of Escherichia coli DXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Escherichia coli (strain K12))
Birla Institute of Technology and Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50406458(CHEMBL5274427)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant Escherichia coli DXR in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Escherichia coli (strain K12))
Birla Institute of Technology and Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50406459(CHEMBL5275507)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of His-tagged Escherichia coli DXR using DXP as substrate incubated for 1 min in presence of NADPH by UV-Vis spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Escherichia coli (strain K12))
Birla Institute of Technology and Science-Pilani

Curated by ChEMBL
LigandPNGBDBM84558(Phosphate analogue, 9)
Affinity DataKi:  6.50E+6nMAssay Description:Inhibition of Escherichia coli DXR assessed as inhibition constant in presence of NADPH by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed