Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50011628
TargetCytochrome P450 2D6(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50030814(CHEMBL2086892)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50030814(CHEMBL2086892)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549530(CHEMBL4788892)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50030814(CHEMBL2086892)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549530(CHEMBL4788892)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549530(CHEMBL4788892)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549530(CHEMBL4788892)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50030814(CHEMBL2086892)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549529(CHEMBL4779819)
Affinity DataKi:  6.60nMAssay Description:Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549533(CHEMBL4779945)
Affinity DataKi:  7.60nMAssay Description:Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549530(CHEMBL4788892)
Affinity DataKi:  9.30nMAssay Description:Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549528(CHEMBL4759641)
Affinity DataKi:  17nMAssay Description:Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549526(CHEMBL4751226)
Affinity DataKi:  26nMAssay Description:Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549527(CHEMBL4784233)
Affinity DataKi:  39nMAssay Description:Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549525(CHEMBL2086911)
Affinity DataKi:  48nMAssay Description:Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549532(CHEMBL4747530)
Affinity DataKi:  53nMAssay Description:Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549531(CHEMBL4762752)
Affinity DataKi:  110nMAssay Description:Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549534(CHEMBL4797684)
Affinity DataKi:  170nMAssay Description:Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50030814(CHEMBL2086892)
Affinity DataKi:  270nMAssay Description:Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549524(CHEMBL2086910)
Affinity DataKi:  280nMAssay Description:Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549530(CHEMBL4788892)
Affinity DataKi: >3.00E+3nMAssay Description:Displacement of [125I]Sar-Ile-angiotensin 2 from human AT1 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed