Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50011472
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547958(CHEMBL4789918)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547947(CHEMBL4760206)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547949(CHEMBL4743091)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547959(CHEMBL4750630)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547955(CHEMBL4796558)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547962(CHEMBL4784665)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547954(CHEMBL4763990)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547953(CHEMBL4790506)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547961(CHEMBL4777409)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547946(CHEMBL4757687)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547963(CHEMBL4757349)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547948(CHEMBL4742305)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547950(CHEMBL4748475)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547965(CHEMBL4741488)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547952(CHEMBL4757094)
Affinity DataIC50: 42nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547956(CHEMBL4748082)
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547947(CHEMBL4760206)
Affinity DataIC50: 59nMAssay Description:Inhibition of IRAK4 in human THP-1 cells assessed as inhibition of LTA-induced TNF-alpha production preincubated for 60 mins followed by LTA stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547960(CHEMBL4755398)
Affinity DataIC50: 63nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547948(CHEMBL4742305)
Affinity DataIC50: 103nMAssay Description:Inhibition of IRAK4 in human THP-1 cells assessed as inhibition of LTA-induced TNF-alpha production preincubated for 60 mins followed by LTA stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547951(CHEMBL4791469)
Affinity DataIC50: 104nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547965(CHEMBL4741488)
Affinity DataIC50: 233nMAssay Description:Inhibition of IRAK4 in human THP-1 cells assessed as inhibition of LTA-induced TNF-alpha production preincubated for 60 mins followed by LTA stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 270nMAssay Description:Inhibition of IRAK4 in human MV4-11 cells assessed as modulation of phospho-IRAK1 level by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547945(CHEMBL4790504)
Affinity DataIC50: 397nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547957(CHEMBL4790895)
Affinity DataIC50: 505nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 514nMAssay Description:Inhibition of IRAK4 in human THP-1 cells assessed as inhibition of LTA-induced TNF-alpha production preincubated for 60 mins followed by LTA stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 696nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of TLR5-mediated FLA-ST-induced IL-6 release preincubated for 1 hr followed by FLA-ST...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547944(CHEMBL4788562)
Affinity DataIC50: 797nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 989nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of TLR2-mediated LTA-induced IL-6 release preincubated for 1 hr followed by LTA stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547967(CHEMBL4757221)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IRAK4 in human THP-1 cells assessed as inhibition of LTA-induced TNF-alpha production preincubated for 60 mins followed by LTA stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547966(CHEMBL4747796)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IRAK4 in human THP-1 cells assessed as inhibition of LTA-induced TNF-alpha production preincubated for 60 mins followed by LTA stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of IL-1R-mediated IL-1beta-induced IL-6 release preincubated for 1 hr followed by IL-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547943(CHEMBL4789126)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed