Compile Data Set for Download or QSAR
Report error Found 71 Enz. Inhib. hit(s) with all data for entry = 50018224
LigandPNGBDBM523252(US11135207, Example 32 | (1r,4r)-4-(4- chloropheny...)
Affinity DataIC50: 1nMAssay Description:Inhibition of DES1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM523251(US11135207, Example 31 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 1nMAssay Description:Inhibition of DES1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM523243(US11135207, Example 20 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 4nMAssay Description:Inhibition of DES1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50407243(CHEMBL5275998)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat liver microsome DES1 using N-octanoylsphinganine as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50407243(CHEMBL5275998)
Affinity DataIC50: 52nMAssay Description:Inhibition of DES1 in human HGC-27 cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM523241(US11135207, Example 15 | N-(4-hydroxy- phenyl)-4- ...)
Affinity DataIC50: 90nMAssay Description:Inhibition of DES1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50092055(CHEMBL7301 | N-(4-hydroxyphenyl)-retinamide | 4-hy...)
Affinity DataIC50: 100nMAssay Description:Inhibition of DES1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50407244(CHEMBL5268107)
Affinity DataIC50: 155nMAssay Description:Inhibition of DES1 in human HGC-27 cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407385(CHEMBL5284450)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant nSMaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCeramide synthase 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50407245(CHEMBL5268405)
Affinity DataIC50: 460nMAssay Description:Inhibition of mouse CerS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407390(CHEMBL5279596)
Affinity DataIC50: 500nMAssay Description:Inhibition of nSMase2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407388(CHEMBL5267817)
Affinity DataIC50: 500nMAssay Description:Inhibition of nSMase2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCeramide synthase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407245(CHEMBL5268405)
Affinity DataIC50: 540nMAssay Description:Inhibition of human CerS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelinase C(Bacillus cereus)
TBA

Curated by ChEMBL
LigandPNGBDBM248063(SMY-540)
Affinity DataIC50: 800nMAssay Description:Inhibition of Bacillus cereus SMaseCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50407382(CHEMBL5280187)
Affinity DataIC50: 860nMAssay Description:Inhibition of mouse nSMaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50407379(CHEMBL5276486)
Affinity DataIC50: 900nMAssay Description:Inhibition of mouse nSMaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelinase C(Bacillus cereus)
TBA

Curated by ChEMBL
LigandPNGBDBM248061(SMY-471)
Affinity DataIC50: 900nMAssay Description:Inhibition of Bacillus cereus SMaseCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50407378(CHEMBL1514251)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rat brain nSMaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407383(CHEMBL5278618)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant nSMaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50100341((2E,4E,6E,12E)-(8R,10S,14R)-8,10,12,14-Tetramethyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407347(CHEMBL5273649)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of aSMase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelinase C(Bacillus cereus)
TBA

Curated by ChEMBL
LigandPNGBDBM248057(RY221B-a)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of Bacillus cereus SMaseCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50407241(CHEMBL5290345)
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of rat liver microsome DES1 incubated for 20 min in presence of NADH by liquid scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407390(CHEMBL5279596)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of AChe (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407249(CHEMBL5273927)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of aSMase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407376(CHEMBL5284579)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of nSMase in human U-937 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50128902(Pyridin-4-ylmethyl-carbamic acid (E)-(2S,3R)-3-hyd...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407248(CHEMBL5271590)
Affinity DataIC50: 1.82E+3nMAssay Description:Inhibition of aSMase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407247(CHEMBL5276301)
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of aSMase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50092055(CHEMBL7301 | N-(4-hydroxyphenyl)-retinamide | 4-hy...)
Affinity DataIC50: 2.32E+3nMAssay Description:Inhibition of rat liver microsome DES1 incubated for 20 min in presence of NADH by liquid scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50407381(CHEMBL5285219)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of mouse nSMaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50407380(CHEMBL5279211)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of mouse nSMaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407377(CHEMBL5270975)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of nSMase in human U-937 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50128891(Pyridin-4-ylmethyl-carbamic acid (E)-(2S,3R)-2-(2,...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50407375(CHEMBL5285849)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50407373(CHEMBL2365779)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM29040(cambinol)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of rat nSMase2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCeramide synthase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50158336(FINGOLIMOD HYDROCHLORIDE | 2-amino-2-(4-octylphene...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of CerS2 in HPAC cells using DHSph as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407388(CHEMBL5267817)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of AChe (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCeramide synthase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407245(CHEMBL5268405)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human CerS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCeramide synthase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50407245(CHEMBL5268405)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of mouse CerS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCeramide synthase 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407245(CHEMBL5268405)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human CerS4More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCeramide synthase 5(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50407245(CHEMBL5268405)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of mouse CerS5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCeramide synthase 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407245(CHEMBL5268405)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human CerS6More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50407371(CHEMBL5284730)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50407242(CHEMBL5277675)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of rat liver microsome DES1 incubated for 1 hr fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50370178(CHEMBL3261720)
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of aSMase (unknown origin) by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50511100(CHEMBL4451474)
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of aSMase (unknown origin) by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingomyelin phosphodiesterase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50214969(Mangostin | alpha-mangostin | 1,3,6-Trihydroxy-7-m...)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of aSMase (unknown origin) by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50407370(CHEMBL5281448)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
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